alpha-苯氧基丁酸钠盐 | 100700-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: alpha-苯氧基丁酸钠盐
• 英文名称: Sodium alpha-phenoxybutyric acid
• 英文别名: sodium;2-phenoxybutanoate
• CAS: 100700-35-4
• 化学式: C10H11NaO3
• 分子量: 202.18
• InChiKey: OWCQJTQGZJVWGI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Arsenic compositions
  申请人：Eupharma Pty Ltd

  公开号：US11241453B2

  公开（公告）日：2022-02-08

  The present invention is predicated on the realisation that problems with the poor water solubility of arsenic trioxide and the extreme difficulty in dissolving arsenic trioxide in anything other than a very basic solution, could be overcome by forming a much more soluble diarsenic tetraoxide, including the compound NaHAs2O4, prior to its delivery to a patient. Pharmaceutical compositions with such compounds and their use in the treatment of cancers is disclosed.

  本发明是基于这样一种认识，即三氧化二砷的水溶性很差，除了非常基本的溶液之外，三氧化二砷极难溶解于其他任何溶液中，而在将其提供给病人之前，可以通过形成溶解性更高的二胂四氧化物（包括化合物 NaHAs2O4）来克服这一问题。含有这种化合物的药物组合物及其在治疗癌症中的用途已被公开。
• ARSENIC COMPOSITIONS
  申请人：Eupharma Pty Ltd

  公开号：EP3548044A1

  公开（公告）日：2019-10-09
• [EN] ARSENIC COMPOSITIONS<br/>[FR] COMPOSITIONS D'ARSENIC
  申请人：EUPHARMA PTY LTD

  公开号：WO2018098519A1

  公开（公告）日：2018-06-07

  The present invention is predicated on the realisation that problems with the poor water solubility of arsenic trioxide and the extreme difficulty in dissolving arsenic trioxide in anything other than a very basic solution, could be overcome by forming a much more soluble diarsenic tetraoxide, including the compound NaHAs2O4, prior to its delivery to a patient. Pharmaceutical compositions with such compounds and their use in the treatment of cancers is disclosed.