1-iodo-1-phenylbutan-3-one | 125763-66-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-iodo-1-phenylbutan-3-one
• 英文别名: 4-Iodo-4-phenylbutan-2-one
• CAS: 125763-66-8
• 化学式: C₁₀H₁₁IO
• 分子量: 274.101
• InChiKey: KHGSUJOXIBEPFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苄叉丙酮 在 碘代三甲硅烷 作用下， 以 氘代氯仿 为溶剂， 反应 0.05h， 以100%的产率得到1-iodo-1-phenylbutan-3-one
  参考文献：
  名称：

  Diiodosilane. 2. A multipurpose reagent for hydrolysis and reductive iodination of ketals, acetals, ketones, and aldehydes

  摘要：

  DOI：

  10.1021/jo00296a068

文献信息

• A NEW PROCESS FOR THE PREPARATION OF LATANOPROST
  申请人：Finetech Laboratories Ltd.

  公开号：EP1252138A2

  公开（公告）日：2002-10-30
• PREPARATION OF 17-PHENYL- 18, 19, 20- TRINOR-PGF2A AND ITS DERIVATIVES
  申请人：Finetech Laboratories Ltd.

  公开号：EP1397347A2

  公开（公告）日：2004-03-17
• KEINAN, E.;PEREZ, D.;SAHAI, M.;SHVILY, R., J. ORG. CHEM., 55,(1990) N, C. 2927-2938
  作者：KEINAN, E.、PEREZ, D.、SAHAI, M.、SHVILY, R.

  DOI：——

  日期：——
• [EN] A NEW PROCESS FOR THE PREPARATION OF LATANOPROST<br/>[FR] NOUVEAU PROCEDE DE PREPARATION DE DU LATANOPROST
  申请人：FINETECH LTD

  公开号：WO2001055101A2

  公开（公告）日：2001-08-02

  Disclosed is a novel process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process.
• [EN] A NEW PROCESS FOR THE PREPARATION OF 17-PHENYL- 18,19,20- TRINOR-PGF2A AND ITS DERIVATIVES<br/>[FR] NOUVEAU PROCEDE DE PREPARATION DE 17-PHENYL-18,19,20-TRINOR-PGF2 DOLLAR G(A) ET DE SES DERIVES
  申请人：FINETECH LAB LTD

  公开号：WO2002096868A2

  公开（公告）日：2002-12-05

  The present invention provides a new and effective process for the synthesis of 17-phenyl-18,19,20-trinor-PGF2α and its derivatives, including the anti-glaucoma drugs Bimatoprost and Latanoprost. The benefit of the present invention rises inter alia from the fact that a major intermediate involved in the synthesis of the above compounds may be isolated from a mixture containing also an undesired isomer, by crystallization. In addition, the undesired isomer may be oxidized to give the starting compound, which is then recycled.