2-tert-Butoxycarbonylamino-2-methyl-butyric acid 4-nitro-phenyl ester | 188922-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2-tert-Butoxycarbonylamino-2-methyl-butyric acid 4-nitro-phenyl ester
• 英文别名: (4-nitrophenyl) 2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
• CAS: 188922-34-1
• 化学式: C₁₆H₂₂N₂O₆
• 分子量: 338.36
• InChiKey: FPCVRKOEYDSKJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-tert-Butoxycarbonylamino-2-methyl-butyric acid 4-nitro-phenyl ester 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 2-tert-Butoxycarbonylamino-2-methyl-butyric acid 4-amino-phenyl ester
  参考文献：
  名称：

  Enzymatic coupling of α,α-dialkyl amino acids using inverse substrates as acyl donors

  摘要：

  Two series of inverse substrates, N-alpha-Boc-alpha,alpha-dialkyl amino acid p-guanidino- and p-(guanidinomethyl)phenyl esters, were prepared as acyl donor components for enzymatic peptide synthesis. They were found to be readily coupled with amino acid p-nitroanilide to produce peptide. Streptomyces griseus trypsin was a more efficient catalyst than bovine trypsin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00167-6
• 作为产物：
  描述：

  对硝基苯酚 、 N-(tert-butoxycarbonyl)-2-amino-2-methylbutanoic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 乙酸乙酯 为溶剂， 生成 2-tert-Butoxycarbonylamino-2-methyl-butyric acid 4-nitro-phenyl ester
  参考文献：
  名称：

  Enzymatic coupling of α,α-dialkyl amino acids using inverse substrates as acyl donors

  摘要：

  Two series of inverse substrates, N-alpha-Boc-alpha,alpha-dialkyl amino acid p-guanidino- and p-(guanidinomethyl)phenyl esters, were prepared as acyl donor components for enzymatic peptide synthesis. They were found to be readily coupled with amino acid p-nitroanilide to produce peptide. Streptomyces griseus trypsin was a more efficient catalyst than bovine trypsin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00167-6