N-[6-(3-bromophenyl)-2-(cyclopropylmethyl)-3-oxo-2,3-dihydropyridazin-4-yl]-N'-(3,5-dichloropyridin-4-yl)urea | 1229442-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[6-(3-bromophenyl)-2-(cyclopropylmethyl)-3-oxo-2,3-dihydropyridazin-4-yl]-N'-(3,5-dichloropyridin-4-yl)urea
• 英文别名: 1-[6-(3-Bromophenyl)-2-(cyclopropylmethyl)-3-oxopyridazin-4-yl]-3-(3,5-dichloropyridin-4-yl)urea
• CAS: 1229442-93-6
• 化学式: C₂₀H₁₆BrCl₂N₅O₂
• 分子量: 509.189
• InChiKey: QEPOFRAKXKTBRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
  申请人：Almirall, S.A.

  公开号：EP2196465A1

  公开（公告）日：2010-06-16

  New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

  揭示了具有化学结构式（I）的新（3-氧代）吡啶并嘧啶-4-基脲衍生物；以及它们的制备方法，包含它们的药物组合物以及它们作为磷酸二酯酶IV（PDE4）抑制剂在治疗中的用途。
• [EN] (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS<br/>[FR] DÉRIVÉS DE (3-OXO)PYRIDIN-4-YLURÉE EN TANT QU'INHIBITEURS DE LA PDE4
  申请人：ALMIRALL SA

  公开号：WO2010069504A1

  公开（公告）日：2010-06-24

  New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).