4,5-dimethylhex-4-enylbenzene | 95340-19-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,5-dimethylhex-4-enylbenzene
• CAS: 95340-19-5
• 化学式: C₁₄H₂₀
• 分子量: 188.313
• InChiKey: SCYLQBYDCWKAIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.37
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  4,5-dimethylhex-4-enylbenzene 生成 7,7,8-trimethyltetracyclo[6.3.0.01,5.04,6]undec-2-ene
  参考文献：
  名称：

  ELLIS-DAVIES, G. C. R.;GILBERT, A.;HEATH, P.;LANE, J. C.;WARRINGTON, J. V+, J. CHEM. SOC. PERKIN TRANS., 1984, N 11, 1833-1841

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4,5-dimethylhex-4-enyl)phenyl trifluoromethanesulfonate 在 palladium diacetate 、 potassium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以72%的产率得到4,5-dimethylhex-4-enylbenzene
  参考文献：
  名称：

  De novo synthesis of teleocidin B analogs

  摘要：

  Teleocidin B analogs have been synthesized in 24 steps and 1.9% overall yield. The key steps include aromatic Claisen rearrangement, intramolecular Heck reaction of a tetra-substituted alkene, and ruthenium (II) catalyzed indole cyclization. Teleocidin and the new analogs promote cell spreading on fibroblast cells that were treated with amino-Nogo, an inhibitor of cell spreading. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.048

文献信息

• Ellis-Davies, Graham C. R.; Gilbert, Andrew; Heath, Peter, Journal of the Chemical Society. Perkin transactions II, 1984, p. 1833 - 1842
  作者：Ellis-Davies, Graham C. R.、Gilbert, Andrew、Heath, Peter、Lane, Jon C.、Warrington, John V.、Westover, David L.

  DOI：——

  日期：——
• Utilization of Potassium Vinyltrifluoroborate in the Development of a 1,2-Dianion Equivalent
  作者：Gary A. Molander、Deidre L. Sandrock

  DOI：10.1021/ol900822j

  日期：2009.6.4

  Previous studies of orthogonally reactive dibora species led to the discovery of a unique reactivity pattern associated with potassium vinyltrifluoroborate. Upon hydroboration, the vinyltrifluoroborate generates a 1,2-diboraethane, which is distinct from the 1,1-dibora intermediates generated when traditional alkenyldialkylboron species undergo hydroboration. The 1,2-dianion equivalent thus generated can be envisioned as a building block for the linkage of two different electrophiles via palladium-catalyzed Suzuki-Miyaura cross-couplings.