N-cyclopropylmethyl-2-(6-methyl-2-p-tolyl-imidazo[1,2-b]pyridazin-3-yl)-N-propyl-acetamide | 951172-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-cyclopropylmethyl-2-(6-methyl-2-p-tolyl-imidazo[1,2-b]pyridazin-3-yl)-N-propyl-acetamide
• 英文别名: N-(cyclopropylmethyl)-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]-N-propylacetamide
• CAS: 951172-05-7
• 化学式: C₂₃H₂₈N₄O
• 分子量: 376.502
• InChiKey: KRIDURBYLLLJEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP1845098A1

  公开（公告）日：2007-10-17

  The invention provides novel imidazo[1,2-b]pyridazines of formula (I) and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing diseases associated with GABAA receptors modulation, anxiety, epilepsy, sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic procedures for preparing said compounds and certain intermediates, as well as intermediates themselves.

  该发明提供了式(I)的新型咪唑并[1,2-b]吡啶嘧啶化合物及其药用可接受的盐、多型体、水合物、互变异构体、溶剂合物和立体异构体。式(I)的化合物可用于治疗或预防与GABAA受体调节、焦虑、癫痫、包括失眠在内的睡眠障碍以及诱导镇静-催眠、麻醉、睡眠和肌肉松弛相关的疾病。该发明还提供了用于制备上述化合物和某些中间体的合成程序，以及中间体本身。
• IMIDAZO [1, 2-B]PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS
  申请人：Ferrer Internacional, S.A.

  公开号：EP2010536B1

  公开（公告）日：2010-06-16
• Imidazo[1,2-B]Pyridazines, Processes, Uses, Intermediates and Compositions
  申请人：Falcó José Luís

  公开号：US20090176788A1

  公开（公告）日：2009-07-09

  The invention provides novel imidazo[1,2-b]pyridazines of formula (I) and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing diseases associated with GABA A receptors modulation, anxiety, epilepsy, sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic procedures for preparing said compounds and certain intermediates, as well as intermediates themselves.
• IMIDAZO[1,2-B]PYRIDAZINES, PROCESSES, USES, INTERMEDIATES AND COMPOSITIONS
  申请人：FALCÓ José Luís

  公开号：US20120040979A1

  公开（公告）日：2012-02-16

  The invention provides novel imidazo[1,2-b]pyridazines of formula (I) and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing diseases associated with GABA A receptors modulation, anxiety, epilepsy, sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic procedures for preparing said compounds and certain intermediates, as well as intermediates themselves.
• US8153789B2
  申请人：——

  公开号：US8153789B2

  公开（公告）日：2012-04-10