2,4-Dihydroxy-5-nitro-<3-nitro-phenyl>-pyrimidin | 23766-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-Dihydroxy-5-nitro-<3-nitro-phenyl>-pyrimidin
• 英文别名: 5-nitro-6-(3-nitro-phenyl)-1H-pyrimidine-2,4-dione；5-nitro-6-(3-nitrophenyl)-1H-pyrimidine-2,4-dione
• CAS: 23766-61-2
• 化学式: C₁₀H₆N₄O₆
• 分子量: 278.181
• InChiKey: OXLBKJOHEDRBCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL URACILS AS ANTICOAGULATIVE AGENTS
  申请人：Pharmacia Corporation

  公开号：EP1178971A1

  公开（公告）日：2002-02-13
• [EN] SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL URACILS AS ANTICOAGULATIVE AGENTS<br/>[FR] ANTICOAGULANTS A BASE D'URACILS D'ARYLE POLYCYCLIQUES ET D'HETEROARYLES
  申请人：MONSANTO CO

  公开号：WO2000069833A1

  公开（公告）日：2000-11-23

  The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
• [EN] SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL URACILS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE<br/>[FR] URACILS D'HETEROARYLE ET D'ARYLE POLYCYCLIQUES SUBSTITUES UTILES POUR L'INHIBITION SELECTIVE DE LA CASCADE DE COAGULATION
  申请人：PHARMACIA CORP

  公开号：WO2001087852A1

  公开（公告）日：2001-11-22

  The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds of formula (I) useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.