4-Ethylpyridazin-3-amine | 1314931-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Ethylpyridazin-3-amine
• CAS: 1314931-11-7
• 化学式: C₆H₉N₃
• mdl: MFCD08460974
• 分子量: 123.16
• InChiKey: FFJICSHBUIEYOT-UHFFFAOYSA-N

物化性质

• 沸点：
  314.6±22.0 °C(Predicted)
• 密度：
  1.109±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Potent gamma-secretase modulators
  申请人：The General Hospital Coporation

  公开号：US10472346B2

  公开（公告）日：2019-11-12

  Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant Aβ peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L′ is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.

  本文提供了用于治疗与 A3 肽水平异常相关的疾病（包括阿尔茨海默病）的化合物和方法。本文提供了用于治疗与 Aβ 肽水平异常相关的疾病（包括 AD）的组合物和方法。本文提供了式(A)化合物或其药学上可接受的盐，其中，L′选自由C(O)、C(R1)(R2)、取代或未取代的-C2-6亚烷基和取代或未取代的-C3-6环亚烷基组成的组。
• POTENT GAMMA-SECRETASE MODULATORS
  申请人：The General Hospital Corporation

  公开号：EP3212633A1

  公开（公告）日：2017-09-06
• [EN] POTENT GAMMA-SECRETASE MODULATORS<br/>[FR] PUISSANTS MODULATEURS DE LA SÉCRÉTASE GAMMA
  申请人：GEN HOSPITAL CORP

  公开号：WO2016070107A1

  公开（公告）日：2016-05-06

  Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant AP peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L' is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted -C2-6 alkylene-, and substituted or unsubstituted -C3-6 cycloalkylene.