2-[(R)-3-Benzyloxycarbonylamino-4-(1H-indol-3-yl)-2-oxo-butyl]-malonic acid dimethyl ester | 135941-65-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(R)-3-Benzyloxycarbonylamino-4-(1H-indol-3-yl)-2-oxo-butyl]-malonic acid dimethyl ester
• CAS: 135941-65-0
• 化学式: C₂₅H₂₆N₂O₇
• 分子量: 466.491
• InChiKey: MUDGNDLCJVDYKJ-OAQYLSRUSA-N

反应信息

• 作为反应物：
  描述：

  2-[(R)-3-Benzyloxycarbonylamino-4-(1H-indol-3-yl)-2-oxo-butyl]-malonic acid dimethyl ester 在 palladium on activated charcoal sodium hydroxide 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 乙酸乙酯 为溶剂， 生成 (R)-6-(1H-Indol-3-ylmethyl)-2,5-dioxo-piperidine-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis of methyl 6-aralkl-2,5-diketopiperidine-3-carboxylates as synthons of conformationally constrained pseudopeptides

  摘要：

  Catalytic hydrogenation of the 4-ketoesters 1a,b or 2a,b and their 5R-enantiomers, obtained from the corresponding Z-L- and Z-D-amino acid halomethyl ketones, directly leads to the methyl 6-aralkyl-2,5-diketopiperidine-3-carboxylates 3a,b and 4a,b and their 6R-enantiomers with high or moderate stereoselectivity at C-3.

  DOI：

  10.1016/0040-4039(91)80834-s