5-amino-3-(3,5-bis(trifluoromethyl)phenyl)thiophene-2,4-dicarbonitrile | 1335000-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-amino-3-(3,5-bis(trifluoromethyl)phenyl)thiophene-2,4-dicarbonitrile
• 英文别名: 5-Amino-3-[3,5-bis(trifluoromethyl)phenyl]thiophene-2,4-dicarbonitrile
• CAS: 1335000-72-0
• 化学式: C₁₄H₅F₆N₃S
• 分子量: 361.27
• InChiKey: CXIGAWZTOWVAEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  5-amino-3-(3,5-bis(trifluoromethyl)phenyl)thiophene-2,4-dicarbonitrile 在 硫酸 、 碳酸氢钠 作用下， 以 水 为溶剂， 以92%的产率得到5-amino-3-(3,5-bis(trifluoromethyl)phenyl)thiophene-2,4-dicarboxamide
  参考文献：
  名称：

  Aminothiophenedicarboxamides and dicyanothiopheneacetamides as effective synthetic molluscicides against Indoplanorbis exustus snail

  摘要：

  New thiophenedicarboxamide 2a-c and dicyanothiopheneacetamide 3a-c derivatives were synthesized and their bioactivity against Indoplanorbis exustus snails was evaluated. The I. exustus snail is a serious host of parasite of genus Schistosoma which infects cattle. Thus reduces livestock productivity and also acts as a source of cercarial dermatitis in human beings. The results obtained show a significant (P < 0.05) molluscicidal activity with LC50 = 0.6043 ppm for compound 2a and LC50 = 0.6511 ppm for compound 3a. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.06.001
• 作为产物：
  描述：

  3,5-三氟甲基苯甲酰基乙腈 、 丙二腈 在 sulfur 作用下， 以85%的产率得到5-amino-3-(3,5-bis(trifluoromethyl)phenyl)thiophene-2,4-dicarbonitrile
  参考文献：
  名称：

  Aminothiophenedicarboxamides and dicyanothiopheneacetamides as effective synthetic molluscicides against Indoplanorbis exustus snail

  摘要：

  New thiophenedicarboxamide 2a-c and dicyanothiopheneacetamide 3a-c derivatives were synthesized and their bioactivity against Indoplanorbis exustus snails was evaluated. The I. exustus snail is a serious host of parasite of genus Schistosoma which infects cattle. Thus reduces livestock productivity and also acts as a source of cercarial dermatitis in human beings. The results obtained show a significant (P < 0.05) molluscicidal activity with LC50 = 0.6043 ppm for compound 2a and LC50 = 0.6511 ppm for compound 3a. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.06.001

文献信息

• Aminothiophenedicarboxamides and dicyanothiopheneacetamides as effective synthetic molluscicides against Indoplanorbis exustus snail
  作者：Shrikant B. Kanawade、Raghunath B. Toche、Shivaraj P. Patil、Ashok E. Desai、Sapana S. Bhamare

  DOI：10.1016/j.ejmech.2011.06.001

  日期：2011.9

  New thiophenedicarboxamide 2a-c and dicyanothiopheneacetamide 3a-c derivatives were synthesized and their bioactivity against Indoplanorbis exustus snails was evaluated. The I. exustus snail is a serious host of parasite of genus Schistosoma which infects cattle. Thus reduces livestock productivity and also acts as a source of cercarial dermatitis in human beings. The results obtained show a significant (P < 0.05) molluscicidal activity with LC50 = 0.6043 ppm for compound 2a and LC50 = 0.6511 ppm for compound 3a. (C) 2011 Elsevier Masson SAS. All rights reserved.