N-{1-[(3aR,4S,6R,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexahydro-furo[3,4-d]isoxazol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide | 181786-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{1-[(3aR,4S,6R,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexahydro-furo[3,4-d]isoxazol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
• CAS: 181786-38-9
• 化学式: C₃₄H₃₈N₄O₅Si
• 分子量: 610.785
• InChiKey: FPMTUOVHEJHWOZ-CGBJDRFBSA-N

反应信息

• 作为反应物：
  描述：

  N-{1-[(3aR,4S,6R,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexahydro-furo[3,4-d]isoxazol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.5h， 生成 N-[1-((3aR,4S,6R,6aS)-6-Hydroxymethyl-2-methyl-hexahydro-furo[3,4-d]isoxazol-4-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide
  参考文献：
  名称：

  Synthesis of [3.3.0] bicyclic isoxazolidinyl nucleosides

  摘要：

  The isoxazolidine derivative 6, prepared from an intermolecular 1,3-dipolar cycloaddition of the (5S)-unsaturated lactone 5 and N-methylnitrone, was effectively used for the synthesis of [3.3.0] bicyclic isoxazolidinyl cytidine 4a and thymidine 4b. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00262-4
• 作为产物：
  描述：

  Acetic acid (3aR,6R,6aS)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-methyl-hexahydro-furo[3,4-d]isoxazol-4-yl ester 在 三氟甲磺酸三甲基硅酯 、 silylated N⁴-benzoylated cytosine 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 N-{1-[(3aR,4S,6R,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexahydro-furo[3,4-d]isoxazol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 、 N-{1-[(3aR,4R,6R,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-hexahydro-furo[3,4-d]isoxazol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
  参考文献：
  名称：

  Synthesis of [3.3.0] bicyclic isoxazolidinyl nucleosides

  摘要：

  The isoxazolidine derivative 6, prepared from an intermolecular 1,3-dipolar cycloaddition of the (5S)-unsaturated lactone 5 and N-methylnitrone, was effectively used for the synthesis of [3.3.0] bicyclic isoxazolidinyl cytidine 4a and thymidine 4b. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00262-4