2-[1-(4,4-difluorocyclohexyl)-3-methyl-1H-pyrazol-4-ylamino]-4-methylaminopyrimidine-5-carbonitrile | 1374828-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[1-(4,4-difluorocyclohexyl)-3-methyl-1H-pyrazol-4-ylamino]-4-methylaminopyrimidine-5-carbonitrile
• 英文别名: 2-[[1-(4,4-Difluorocyclohexyl)-3-methylpyrazol-4-yl]amino]-4-(methylamino)pyrimidine-5-carbonitrile
• CAS: 1374828-67-7
• 化学式: C₁₆H₁₉F₂N₇
• 分子量: 347.371
• InChiKey: FUOHOCUYFKYXCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  91.4
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS<br/>[FR] DÉRIVÉS DE PYRAZOLE AMINOPYRIMIDINE EN TANT QUE MODULATEURS DU LRRK2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012062783A1

  公开（公告）日：2012-05-18

  Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

  化合物的结构式（I）或其药用盐，其中X，R1，R2，R3，R4和R5如本文所定义。还公开了制备这些化合物的方法，并将这些化合物用于治疗与LRRK2受体相关的疾病，如帕金森病。
• PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
  申请人：Baker-Glenn Charles

  公开号：US20120157427A1

  公开（公告）日：2012-06-21

  Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

  化合物I的公式为：或其药学上可接受的盐，其中X，R1，R2，R3，R4和R5如本文所定义。还公开了制备该化合物的方法以及使用该化合物治疗与LRRK2受体相关的疾病，如帕金森病的方法。
• SENSOR AND CONCENTRATION MEASUREMENT METHOD
  申请人：Panasonic Corporation

  公开号：EP2474825A1

  公开（公告）日：2012-07-11

  A reagent layer (4) of a sensor (1) contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor 1.

  传感器（1）的试剂层（4）含有一种具有亲水官能团的醌化合物、菲醌和/或菲醌衍生物作为介质。醌化合物的氧化还原电位比传统介质低，因此干扰物质对传感器 1 检测结果的影响较小。
• REAGENT COMPOSITION, SENSOR, SENSOR SYSTEM, AND SENSOR MANUFACTURE PROCESS
  申请人：Panasonic Corporation

  公开号：EP2623974A1

  公开（公告）日：2013-08-07

  The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.

  本发明提供：一种具有更高贮存稳定性的试剂组合物；一种涉及该试剂组合物的传感器；以及其他。根据本发明，在试剂组合物中添加特定的杂环化合物，以提高试剂组合物的储存稳定性，并降低使用试剂组合物的传感器中电流值的波动程度。
• SENSOR
  申请人：Panasonic Healthcare Holdings Co., Ltd.

  公开号：EP3343213A2

  公开（公告）日：2018-07-04

  The present invention provides a sensor for detecting or quantifying a target substance contained in a liquid sample. The sensor comprises a quinone compound that accepts electrons released as a result of dehydrogenation or oxidization of the target substance by the enzyme; and at least a pair of electrodes, wherein the quinone compound contains a quinone and a substituent, wherein the substituent is hydrophilic. The quinone compound has a lower redox potential than conventional substances, so interfering substances have less effect on detection results with this sensor, particularly the redox potential of the quinone compound measured using a silver/silver chloride (saturated potassium chloride) electrode as a reference electrode is more negative than the oxidization potential of ascorbic acid.

  本发明提供了一种用于检测或量化液体样品中所含目标物质的传感器。该传感器由醌化合物和至少一对电极组成，其中醌化合物含有醌和取代基，取代基为亲水性。醌化合物的氧化还原电位低于传统物质，因此干扰物质对该传感器检测结果的影响较小，特别是使用银/氯化银（饱和氯化钾）电极作为参比电极测量的醌化合物的氧化还原电位比抗坏血酸的氧化电位更负。