(4E)-5-methyl-4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylidene]nonan-5-ol | 1351998-91-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硼酸衍生物
• 英文名称: (4E)-5-methyl-4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylidene]nonan-5-ol
• CAS: 1351998-91-8
• 化学式: C₁₇H₃₃BO₃
• 分子量: 296.258
• InChiKey: MCRQUIUXIRWANL-BUHFOSPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.29
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-己酮 、 2-(1-戊炔基)-4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷 在 正丁基锂 、 二氯二茂锆 、 三丁基膦 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到(4E)-5-methyl-4-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylidene]nonan-5-ol
  参考文献：
  名称：

  Novel 3-hydroxy vinylboronates influence sphingolipid metabolism, cause apoptosis in Jurkat cells and prevent tumor development in nude mice

  摘要：

  A series of novel 3-hydroxy vinylboronates which share structural similarities with sphingolipids were synthesized and tested in vitro and in vivo as anticancer agents. The molecules reduced cancer cell survival in vitro by influencing their sphingolipid metabolism. In a cancer model in nude mice the lead compound E7 prevented the development of tumor as long as the treatment period continued. Moreover, it delayed tumor growth after the treatment was finished. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.028

文献信息

• Novel 3-hydroxy vinylboronates influence sphingolipid metabolism, cause apoptosis in Jurkat cells and prevent tumor development in nude mice
  作者：Alina Botvinik Livshits、Abed Al Aziz Al Quntar、Zhanna Yekhtin、Morris Srebnik、Arie Dagan

  DOI：10.1016/j.bmcl.2012.11.028

  日期：2013.1

  A series of novel 3-hydroxy vinylboronates which share structural similarities with sphingolipids were synthesized and tested in vitro and in vivo as anticancer agents. The molecules reduced cancer cell survival in vitro by influencing their sphingolipid metabolism. In a cancer model in nude mice the lead compound E7 prevented the development of tumor as long as the treatment period continued. Moreover, it delayed tumor growth after the treatment was finished. (C) 2012 Elsevier Ltd. All rights reserved.