Poly(oxy-1,2-ethanediyl), I+/-,I+/-a(2),I+/-a(2)a(2),I+/-a(2)a(2)a(2)-(oxydi-3,1,2-propanetriyl)tetrakis[I-hydroxy- | 110134-52-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: Poly(oxy-1,2-ethanediyl), I+/-,I+/-a(2),I+/-a(2)a(2),I+/-a(2)a(2)a(2)-(oxydi-3,1,2-propanetriyl)tetrakis[I-hydroxy-
• 英文别名: 2-[3-[2,3-bis(2-hydroxyethoxy)propoxy]-2-(2-hydroxyethoxy)propoxy]ethanol
• CAS: 110134-52-6
• 化学式: C₁₄H₃₀O₉
• 分子量: 342.38
• InChiKey: MEFZLFOJUDGENC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
  申请人：Zhao Hong

  公开号：US20070197575A1

  公开（公告）日：2007-08-23

  A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

  披露了一种四臂聚乙二醇-7-乙基-10-羟基喜树碱共轭物，以及制备这些共轭物的方法和利用它们治疗哺乳动物的方法。
• TREATMENT OF NEUROBLASTOMA WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN
  申请人：Pastorino Fabio

  公开号：US20100098654A1

  公开（公告）日：2010-04-22

  The present invention relates to methods of treatment of neuroblastoma. The present invention includes administering polymeric prodrugs of 7-ethyl-10-hydroxycamptothecin to patients in need thereof.

  本发明涉及神经母细胞瘤的治疗方法。本发明包括向需要的患者施用7-乙基-10-羟基喜树碱的聚合物前药。
• TARGETED POLYMERIC PRODRUGS CONTAINING MULTIFUNCTIONAL LINKERS
  申请人：ZHAO Hong

  公开号：US20100233190A1

  公开（公告）日：2010-09-16

  The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.

  本发明提供了含有多功能连接剂的单链抗体导向的聚合物前药。还揭示了制备聚合物传递系统的方法以及利用这些方法治疗哺乳动物的方法。
• POLYMERIC DRUG DELIVERY SYSTEMS CONTAINING AN AROMATIC ALLYLIC ACID
  申请人：ZHAO Hong

  公开号：US20090017004A1

  公开（公告）日：2009-01-15

  The present invention provides polymeric delivery systems including an aromatic allyllic acyl group. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.

  本发明提供了包括芳香烯丙基酰基团的高分子递送系统。还公开了制备这种高分子递送系统的方法以及利用它们治疗哺乳动物的方法。
• USE OF ADENOSINE DEAMINASE FOR TREATING PULMONARY DISEASE
  申请人：Blackburn Michael R.

  公开号：US20080159964A1

  公开（公告）日：2008-07-03

  Provided are methods for treating an adenosine deaminase-mediated pulmonary disease such as asthma, pulmonary fibrosis, cystic fibrosis and chronic obstructive pulmonary disease in a mammal in need thereof, by administering and effective amount of a polymer-conjugated adenosine deaminase.