Acetic acid (2R,3R,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-6-((2R,3R,4S,5S,6R)-2,5-diacetoxy-6-methyl-3-phenylselanyl-tetrahydro-pyran-4-yloxy)-5-phenylsulfanyl-2-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran-3-yl ester | 154367-77-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Acetic acid (2R,3R,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-6-((2R,3R,4S,5S,6R)-2,5-diacetoxy-6-methyl-3-phenylselanyl-tetrahydro-pyran-4-yloxy)-5-phenylsulfanyl-2-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran-3-yl ester
• CAS: 154367-77-8
• 化学式: C₄₃H₅₆O₁₃S₂SeSi
• 分子量: 952.087
• InChiKey: HRYSXRZDPKTEFW-GSJJYOMLSA-N

物化性质

• 沸点：
  862.9±65.0 °C(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.35
• 重原子数：
  60.0
• 可旋转键数：
  15.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  159.19
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  Acetic acid (2R,3R,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-6-((2R,3R,4S,5S,6R)-2,5-diacetoxy-6-methyl-3-phenylselanyl-tetrahydro-pyran-4-yloxy)-5-phenylsulfanyl-2-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran-3-yl ester 在 三苯基膦 、 肼 、 偶氮二甲酸二乙酯 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 [(2R,3S,4S,5R,6S)-4-[(2S,3R,4S,5R,6R)-5-acetyloxy-4-[tert-butyl(dimethyl)silyl]oxy-6-[(4-methylphenyl)sulfonyloxymethyl]-3-phenylsulfanyloxan-2-yl]oxy-2-methyl-6-naphthalen-2-yloxy-5-phenylselanyloxan-3-yl] acetate
  参考文献：
  名称：

  Synthesis of naphthyl A–B disaccharides corresponding to olivomycin A and mithramycin

  摘要：

  Highly stereoselective syntheses of naphthyl disaccharides 4 and 5, which correspond to the A-B disaccharide units of olivomycin A and mithramycin, are described.

  DOI：

  10.1016/s0040-4039(00)91806-9
• 作为产物：
  描述：

  4-O-acetyl-3-O-((triethyl)silyl)-D-fucal 在 三氟甲磺酸三甲基硅酯 4 A molecular sieve 、 氟化氢吡啶 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 Acetic acid (2R,3R,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-6-((2R,3R,4S,5S,6R)-2,5-diacetoxy-6-methyl-3-phenylselanyl-tetrahydro-pyran-4-yloxy)-5-phenylsulfanyl-2-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Synthesis of naphthyl A–B disaccharides corresponding to olivomycin A and mithramycin

  摘要：

  Highly stereoselective syntheses of naphthyl disaccharides 4 and 5, which correspond to the A-B disaccharide units of olivomycin A and mithramycin, are described.

  DOI：

  10.1016/s0040-4039(00)91806-9