摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

Phenyl phenylphosphonazidate | 62188-14-1

中文名称
——
中文别名
——
英文名称
Phenyl phenylphosphonazidate
英文别名
[azido(phenyl)phosphoryl]oxybenzene
Phenyl phenylphosphonazidate化学式
CAS
62188-14-1
化学式
C12H10N3O2P
mdl
——
分子量
259.2
InChiKey
ZTHPLCYNQJKOEH-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.1
  • 重原子数:
    18
  • 可旋转键数:
    4
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    40.7
  • 氢给体数:
    0
  • 氢受体数:
    4

文献信息

  • 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle
    申请人:Sekiguchi Yoshinori
    公开号:US20080318923A1
    公开(公告)日:2008-12-25
    It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.
    旨在提供一种对与精氨酸加压素V1b受体相关的病理状况具有疗效的药物。更具体地说,旨在提供一种对抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、消化系统疾病、药物成瘾、癫痫、脑梗死、脑缺血、脑水肿、头部损伤、炎症、免疫疾病、脱发等具有治疗或预防作用的药物。经过深入研究,发现了一种新颖的1,3-二氢-2H-吲哚-2-酮化合物和与杂芳环融合的吡咯烷-2-酮化合物,它们是高度选择性的精氨酸加压素V1b受体拮抗剂,具有高代谢稳定性,表现出有利的血脑屏障穿透和高血浆浓度,从而实现了上述目标。
  • [EN] PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION<br/>[FR] COMPOSÉS PYRAZOLO[3,4-D]PYRIMIDINONE UTILISÉS EN TANT QU'INHIBITEURS DE L'INTERACTION P53/MDM2
    申请人:NOVARTIS AG
    公开号:WO2014115080A1
    公开(公告)日:2014-07-31
    The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
    本发明涉及式(I)的化合物,如本文所述,包括这种化合物的药物制剂,以及在治疗由MDM2和/或MDM4活性介导的疾病或疾病中使用这种化合物的用途和方法,以及包括这种化合物的组合物。
  • PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION
    申请人:FURET Pascal
    公开号:US20150353563A1
    公开(公告)日:2015-12-10
    The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
    本发明涉及公式(I)的化合物,如本文所述,包括这些化合物的药物制剂,在治疗由MDM2和/或MDM4活性介导的疾病或紊乱中使用这些化合物的用途和方法,以及包含这些化合物的组合物。
  • Aryl diazabicyclyl amides, a process for their preparation and use
    申请人:BEECHAM GROUP PLC
    公开号:EP0047620A1
    公开(公告)日:1982-03-17
    Compounds of formula (I): and pharmaceutically acceptable salts and N-oxides thereof, wherein: a and b are separately 0, 1 or 2; X is -CO-NR- wherein R is hydrogen or C1-4 alkyl, or -NH-CO-; R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen, halogen, CF3, C1-7 acyl, C1-7 acylamino, C1-6 alkyl-S(O)n wherein n is 0, 1 or 2, nitro or amino, C1-6 alkoxy, aminocarbonyl or aminosulphonyl optionally substituted by one or two C1-6 alkyl groups; or R1 and R2 taken together an adjacent carbon atoms are methylenedioxy or ethylenedioxy in which case R3 is any one of the groups given for R2 and R3 above; and either R4 is hydrogen, C1-6 alkyl or phenyl; and R5 is hydrogen; in which case when a and b are 1 and R4 and R5 are both hydrogen then the dotted line may represent a double bond between the two adjacent carbon atoms (in the R4/R5 substituted ring) opposing the two adjacent nitrogen atoms; or R4 and R5 are attached to two adjacent carbon atoms and form together with these two carbon atoms a fused benzene ring, which benzene ring may be substituted by C1-6 alkyl, C1-6 alkoxy, CF3 or halogen; there being a minimum of two carbon atoms between the amide nitrogen and each of the ring nitrogens having useful pharmacological activity, a process for their preparation and their use.
    式(I)化合物: 及其药学上可接受的盐类和 N-氧化物,其中 a 和 b 分别为 0、1 或 2; X 是-CO-NR-,其中 R 是氢或 C1-4 烷基,或-NH-CO-; R1 是 C1-6 烷氧基; R2 和 R3 相同或不同,并且是氢、卤素、CF3、C1-7-酰基、C1-7-酰氨基、C1-6-烷基-S(O)n(其中 n 为 0、1 或 2)、硝基或氨基、C1-6-烷氧基、氨基羰基或氨基磺酰基,任选被一个或两个 C1-6 烷基取代; 或相邻碳原子上的 R1 和 R2 为亚甲基二氧基或亚乙基二氧基,在这种情况下,R3 为上述 R2 和 R3 所含的任一基团; 以及 R4 是氢、C1-6 烷基或苯基;R5 是氢;在这种情况下,当 a 和 b 均为 1 且 R4 和 R5 均为氢时,虚线可代表两个相邻碳原子(在 R4/R5 取代的环中)之间的双键,与两个相邻氮原子相对; 或 R4 和 R5 连接到两个相邻的碳原子上,并与这两个碳原子一起形成一个融合苯环,该苯环可被 C1-6 烷基、C1-6 烷氧基、CF3 或卤素取代; 在酰胺氮和每个环状硝基之间至少有两个碳原子,具有有用的药理活性、制备方法和用途。
  • US5475013A
    申请人:——
    公开号:US5475013A
    公开(公告)日:1995-12-12
查看更多

同类化合物

(βS)-β-氨基-4-(4-羟基苯氧基)-3,5-二碘苯甲丙醇 (S)-(-)-7'-〔4(S)-(苄基)恶唑-2-基]-7-二(3,5-二-叔丁基苯基)膦基-2,2',3,3'-四氢-1,1-螺二氢茚 (S)-盐酸沙丁胺醇 (S)-3-(叔丁基)-4-(2,6-二甲氧基苯基)-2,3-二氢苯并[d][1,3]氧磷杂环戊二烯 (S)-2,2'-双[双(3,5-三氟甲基苯基)膦基]-4,4',6,6'-四甲氧基联苯 (S)-1-[3,5-双(三氟甲基)苯基]-3-[1-(二甲基氨基)-3-甲基丁烷-2-基]硫脲 (R)富马酸托特罗定 (R)-(-)-盐酸尼古地平 (R)-(+)-7-双(3,5-二叔丁基苯基)膦基7''-[((6-甲基吡啶-2-基甲基)氨基]-2,2'',3,3''-四氢-1,1''-螺双茚满 (R)-3-(叔丁基)-4-(2,6-二苯氧基苯基)-2,3-二氢苯并[d][1,3]氧杂磷杂环戊烯 (R)-2-[((二苯基膦基)甲基]吡咯烷 (N-(4-甲氧基苯基)-N-甲基-3-(1-哌啶基)丙-2-烯酰胺) (5-溴-2-羟基苯基)-4-氯苯甲酮 (5-溴-2-氯苯基)(4-羟基苯基)甲酮 (5-氧代-3-苯基-2,5-二氢-1,2,3,4-oxatriazol-3-鎓) (4S,5R)-4-甲基-5-苯基-1,2,3-氧代噻唑烷-2,2-二氧化物-3-羧酸叔丁酯 (4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮 (4-丁氧基苯甲基)三苯基溴化磷 (3aR,8aR)-(-)-4,4,8,8-四(3,5-二甲基苯基)四氢-2,2-二甲基-6-苯基-1,3-二氧戊环[4,5-e]二恶唑磷 (2Z)-3-[[(4-氯苯基)氨基]-2-氰基丙烯酸乙酯 (2S,3S,5S)-5-(叔丁氧基甲酰氨基)-2-(N-5-噻唑基-甲氧羰基)氨基-1,6-二苯基-3-羟基己烷 (2S,2''S,3S,3''S)-3,3''-二叔丁基-4,4''-双(2,6-二甲氧基苯基)-2,2'',3,3''-四氢-2,2''-联苯并[d][1,3]氧杂磷杂戊环 (2S)-(-)-2-{[[[[3,5-双(氟代甲基)苯基]氨基]硫代甲基]氨基}-N-(二苯基甲基)-N,3,3-三甲基丁酰胺 (2S)-2-[[[[[[((1R,2R)-2-氨基环己基]氨基]硫代甲基]氨基]-N-(二苯甲基)-N,3,3-三甲基丁酰胺 (2-硝基苯基)磷酸三酰胺 (2,6-二氯苯基)乙酰氯 (2,3-二甲氧基-5-甲基苯基)硼酸 (1S,2S,3S,5S)-5-叠氮基-3-(苯基甲氧基)-2-[(苯基甲氧基)甲基]环戊醇 (1-(4-氟苯基)环丙基)甲胺盐酸盐 (1-(3-溴苯基)环丁基)甲胺盐酸盐 (1-(2-氯苯基)环丁基)甲胺盐酸盐 (1-(2-氟苯基)环丙基)甲胺盐酸盐 (-)-去甲基西布曲明 龙胆酸钠 龙胆酸叔丁酯 龙胆酸 龙胆紫 龙胆紫 齐达帕胺 齐诺康唑 齐洛呋胺 齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯 齐培丙醇 齐咪苯 齐仑太尔 黑染料 黄酮,5-氨基-6-羟基-(5CI) 黄酮,6-氨基-3-羟基-(6CI) 黄蜡,合成物 黄草灵钾盐