TT-301 hydrochloride | 1346545-21-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: TT-301 hydrochloride
• 英文别名: 6-phenyl-4-pyridin-4-yl-3-(4-pyrimidin-2-ylpiperazin-1-yl)pyridazine;hydrochloride
• CAS: 1346545-21-8
• 化学式: C23H22ClN7
• 分子量: 431.9
• InChiKey: NWSJMKBCHOMUNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.74
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  70.9
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM INJURIES<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE LÉSIONS DU SYSTÈME NERVEUX CENTRAL
  申请人：WARATAH PHARMACEUTICALS INC

  公开号：WO2011137511A1

  公开（公告）日：2011-11-10

  The invention relates to compositions comprising 6-phenyl-4-pyridin-4-yl-3-(4-pyrimidin-2-ylpiperazin-1-yl) pyridazine, or a pharmaceutically acceptable salt thereof, and use of the compositions to treat central nervous system injuries such as traumatic brain injury or intracerebral hemorrhage, in a subject.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS POUR TRAITER LA SCLÉROSE EN PLAQUES
  申请人：WARATAH PHARMACEUTICALS INC

  公开号：WO2011156900A2

  公开（公告）日：2011-12-22

  The invention relates to compounds, compositions dosage forms and methods comprising 6-phenyl-4-pyridin-4-yl-3-(4-pyrimidin-2-yl-piperazin-1-yl)-pyridazine hydrochloride or a pharmaceutically acceptable salt thereof, and methods for treating multiple sclerosis in a subject using same.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF ARTHRITIS<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE L'ARTHRITE
  申请人：WARATAH PHARMACEUTICALS INC

  公开号：WO2012012890A1

  公开（公告）日：2012-02-02

  The invention relates to compounds, compositions, formulations and dosage forms comprising 6-phenyl-4-pyridin-4-yl-3-(4-pyrimidin-2-yl-piperazin-l-yl)- pyridazine, or a pharmaceutically acceptable salt thereof, and methods for treating arthritis in a subject using such compounds, compositions, formulations and dosage forms.