2-[2-(3,4-Dimethoxyphenyl)ethenyl]-4H-3,1-benzoxazin-4-one | 64258-27-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(3,4-Dimethoxyphenyl)ethenyl]-4H-3,1-benzoxazin-4-one
• 英文别名: 2-[2-(3,4-dimethoxyphenyl)ethenyl]-3,1-benzoxazin-4-one
• CAS: 64258-27-1
• 化学式: C₁₈H₁₅NO₄
• 分子量: 309.3
• InChiKey: ZWWUBZYDOACBQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS<br/>[FR] ANALOGUES À CYCLES CONDENSÉS D'AGENTS ANTI-FIBROTIQUES
  申请人：FIBROTECH THERAPEUTICS PTY LTD

  公开号：WO2011047432A1

  公开（公告）日：2011-04-28

  The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.

  本发明涉及可能用作抗纤维化剂的芳基羰基和杂芳基羰基蒽酰胺化合物。本发明还涉及它们的制备方法、含有这些化合物的药物组合物以及这些化合物在治疗疾病中的用途。
• FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS
  申请人：Williams Spencer John

  公开号：US20120270863A1

  公开（公告）日：2012-10-25

  The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment disorders.

  本发明涉及芳基羰基和杂环芳基羰基蒽酰胺化合物，可用作抗纤维化剂。本发明还涉及它们的制备方法，含有这些化合物的制药组合物以及这些化合物在治疗疾病中的用途。
• N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID
  申请人：KOHJIN CO. Ltd.

  公开号：EP0452504A1

  公开（公告）日：1991-10-23

  A method of directly producing N-(3',4'-dimethoxycinnamoyl)anthranilic acid readily in a high yield without being accompanied by the formation of difficultly separable by-products, which comprises either reacting 3',4'-dimethoxycinnamic acid with anthranilic acid in an aprotic polar solvent in the presence of both a specified inorganic salt and an iminium salt which can be quantitatively prepared from dimethylformamide and an inexpensive acyl halide reagent, or reacting 3',4'-dimethoxycinnamic acid with the iminium salt and then with an anthranilic acid-inorganic salt complex which is a new compound not found in any literature. This method makes it possible to produce an objective compound at a high yield without the necessity for using a basic substance or an amine in a large amount sufficient for neutralizing an acid to be generated as a by-product in the condensation unlike known methods, and is scarcely accompanied by the formation of by-products, especially those which are difficult to separate.

  一种高产率地直接生产 N-(3',4'-二甲氧基肉桂酰基)氨茴酸而不伴有难以分离的副产物形成的方法，该方法包括使 3'.4'-二甲氧基肉桂酸与氨茴酸在非沸腾极性溶剂中在指定的无机盐和亚氨基盐的存在下反应、4'-二甲氧基肉桂酸与蚁酸在特定的无机盐和亚胺盐（可从二甲基甲酰胺和廉价的酰基卤化试剂中定量制备）的存在下，在非沸腾极性溶剂中反应，或者将 3',4'-二甲氧基肉桂酸与亚胺盐反应，然后与蚁酸-无机盐复合物反应，该复合物是一种未在任何文献中发现的新化合物。与已知方法不同的是，这种方法无需大量使用碱性物质或胺来中和缩合过程中产生的副产物酸，就能以高产率生产出目标化合物，而且几乎不会产生副产物，尤其是难以分离的副产物。
• 2-ACYLAMINOBENZAMIDE DERIVATIVES AND PREVENTIVE AND REMEDY FOR DISEASES CAUSED BY THE SUPERMULTIPLICATION OF VASCULAR INTIMAL CELLS
  申请人：KISSEI PHARMACEUTICAL CO., LTD.

  公开号：EP0855387A1

  公开（公告）日：1998-07-29

  The present invention relates to 2-acylaminobenzamide derivatives represented by the general formula: wherein R1, R2, R3, R4 and R5 represent each a hydrogen atom etc.; X represents a vinylene group etc.; B represents a group represented by the general formula:         -N(R6)(R7) wherein R6 and R7 represent each a hydrogen atom etc., a group represented by the general formula:         -NH-(CH2)n-A-R8 wherein A represents a single bond etc.; R8 represents a hydroxy group etc. or a hydroxyamino group which are useful as agents for the prevention and treatment of diseases caused by excessive proliferation of vascular intimal cells.

  本发明涉及由通式表示的 2-酰氨基苯甲酰胺衍生物： 其中R1、R2、R3、R4和R5分别代表氢原子等；X代表乙烯基等；B代表通式所代表的基团： -N(R6)(R7) 其中 R6 和 R7 各自代表一个氢原子等；B 代表由通式表示的基团： -NH-(CH2)n-A-R8 其中 A 代表单键等；R8 代表羟基等或羟基氨基，它们可用作预防和治疗因血管内膜细胞过度增殖而引起的疾病的药物。
• JPH0597825A
  申请人：——

  公开号：JPH0597825A

  公开（公告）日：1993-04-20