(5-Chlorobenzo[b]thiophen-2-yl)boronic acid | 867381-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: (5-Chlorobenzo[b]thiophen-2-yl)boronic acid
• 英文别名: (5-chloro-1-benzothiophen-2-yl)boronic acid
• CAS: 867381-22-4
• 化学式: C₈H₆BClO₂S
• 分子量: 212.46
• InChiKey: YNTMDEYDNLWCLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.23
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(5-Chloro-3-methylbenzo[b]thiophen-2-yl)pyrimidin-2-amine 、 苯并噻吩-2-硼酸 、 (5-Chlorobenzo[b]thiophen-2-yl)boronic acid 生成 4-(2-benzo[b]thienyl)-2-pyrimidinamine
  参考文献：
  名称：

  BENZOTHIOPHENE INHIBITORS OF RHO KINASE

  摘要：

  本发明涉及化合物和方法，可用作Rho激酶的抑制剂，用于治疗或预防疾病。

  公开号：

  US20080021026A1
• 作为产物：
  描述：

  5-氯苯并噻吩 、 正丁基锂 、 正己烷 、 硼酸三异丙酯 、 盐酸 在 Sodium sulfate-III 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 0.5h， 以to give 2.15 g of compound dd (white powder的产率得到(5-Chlorobenzo[b]thiophen-2-yl)boronic acid
  参考文献：
  名称：

  Thio-substituted biaryl-methanesulfinyl derivatives

  摘要：

  本发明涉及化学组合物、其制备方法和组合物的用途。特别地，本发明涉及包含式(I)中的取代双芳基甲烷磺酰乙酰胺的组合物：其中Ar、Y、R1、R2、R4、R5、q和x如本文所定义；以及它们在治疗疾病方面的用途，包括治疗与嗜睡症、阻塞性睡眠呼吸暂停或轮班工作障碍有关的嗜睡症、帕金森病、阿尔茨海默病、注意力缺陷障碍、注意力缺陷过动症、抑郁症或与神经系统疾病有关的疲劳，以及促进清醒。

  公开号：

  US07449481B2

文献信息

• Thio-Substituted Biarylmethanesulfinyl Derivatives
  申请人：Bacon Edward R.

  公开号：US20090062284A1

  公开（公告）日：2009-03-05

  The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R 1 , R 2 , R 4 , R 5 , q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

  本发明涉及化学成分、其制备过程和成分的用途。特别地，本发明涉及包括式(I)中的取代的双芳基甲烷磺酰乙酰胺的组合物：其中Ar、Y、R1、R2、R4、R5、q和x如本文中所定义的；以及它们在治疗疾病中的应用，包括治疗与纳考雷普西、阻塞性睡眠呼吸暂停或轮班工作障碍相关的嗜睡症；帕金森病；阿尔茨海默病；注意力缺陷障碍；注意力缺陷多动障碍；抑郁症；或与神经疾病相关的疲劳，以及促进清醒。
• Thio-substituted biaryl-methanesulfinyl derivatives
  申请人：Cephalon, Inc.

  公开号：US07449481B2

  公开（公告）日：2008-11-11

  The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

  本发明涉及化学组合物、其制备方法和组合物的用途。特别地，本发明涉及包含式(I)中的取代双芳基甲烷磺酰乙酰胺的组合物：其中Ar、Y、R1、R2、R4、R5、q和x如本文所定义；以及它们在治疗疾病方面的用途，包括治疗与嗜睡症、阻塞性睡眠呼吸暂停或轮班工作障碍有关的嗜睡症、帕金森病、阿尔茨海默病、注意力缺陷障碍、注意力缺陷过动症、抑郁症或与神经系统疾病有关的疲劳，以及促进清醒。
• BENZOTHIOPHENE INHIBITORS OF RHO KINASE
  申请人：Kahraman Mehmet

  公开号：US20080021026A1

  公开（公告）日：2008-01-24

  The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.

  本发明涉及化合物和方法，可用作Rho激酶的抑制剂，用于治疗或预防疾病。
• Thio-substituted biarylmethanesulfinyl derivatives
  申请人：Cephalon, Inc.

  公开号：US07981907B2

  公开（公告）日：2011-07-19

  The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

  本发明涉及化学组合物，其制备方法和组合物的用途。特别地，本发明涉及包括式（I）中的取代双芳基甲烷基磺酰乙酰胺的组合物： 其中Ar，Y，R1，R2，R4，R5，q和x如本文所定义；以及它们在治疗疾病中的应用，包括治疗与嗜睡症、阻塞性睡眠呼吸暂停或轮班工作障碍相关的嗜睡症、帕金森病、阿尔茨海默病、注意力缺陷障碍、注意力缺陷多动障碍、抑郁症或神经疾病相关的疲劳，以及促进清醒。