N-Methyl esomeprazole | 1820041-19-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-Methyl esomeprazole
• 英文别名: 5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1-methylbenzimidazole
• CAS: 1820041-19-7
• 化学式: C₁₈H₂₁N₃O₃S
• 分子量: 359.4
• InChiKey: RUGQJBJNYIHOIW-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  85.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Methods and compounds to inhibit enveloped virus release
  申请人：Northwestern University

  公开号：US10300080B2

  公开（公告）日：2019-05-28

  A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.

  本发明公开了一种具有抗病毒活性的化合物，用于抑制包膜病毒从细胞中释放，包括抑制包膜病毒从细胞中释放的方法。该化合物的抗病毒活性包括抑制缔合复合物的形成或破坏缔合复合物的形成。关联复合物包括包膜病毒的 L-结构域基团和至少一种能够结合包膜病毒 L-结构域基团的细胞多肽或其片段。
• Methods and Compounds to Inhibit Enveloped Virus Release
  申请人：Northwestern University

  公开号：US20200368258A1

  公开（公告）日：2020-11-26

  A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.