N-benzyl-5-chloro-N-(indan-2-yl)-2-thien-3-ylbenzamide | 610795-05-6

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: N-benzyl-5-chloro-N-(indan-2-yl)-2-thien-3-ylbenzamide
• 英文别名: N-benzyl-5-chloro-N-(2,3-dihydro-1H-inden-2-yl)-2-thiophen-3-ylbenzamide
• CAS: 610795-05-6
• 化学式: C₂₇H₂₂ClNOS
• 分子量: 443.997
• InChiKey: ZEDIUFLCJAERJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  48.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS<br/>[FR] BIARYLAMIDES SUBSTITUES EN TANT QUE MODULATEURS DU RECEPTEUR C5A
  申请人：NEUROGEN CORP

  公开号：WO2003082826A1

  公开（公告）日：2003-10-09

  Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式I的取代联苯酰胺。这些化合物是配体，可用于调节体内或体外的C5a受体活性，并且在治疗与人类、驯养伴侣动物和家畜动物中的C5a受体病理激活相关的疾病方面特别有用。提供了用于治疗此类疾病的药物组合物和使用它们的方法，以及用于受体定位研究的这类配体的方法。
• Composition and use
  申请人：Hodge John David

  公开号：US20050008534A1

  公开（公告）日：2005-01-13

  The present invention relates to a composition comprising: (i) an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and (ii) an amphoteric co-polymer of the Formula (1): wherein: [A] is of Formula (9), [B] is of Formula (10), [C] is of Formula (12), [D] is of Formula (13), and X is of Formula (11), wherein [A], [B], [C] and [D] may occur in any order; T is an optionally substituted substituent; L, G and Z each independently is an optionally substituted linking group; R 1 , R 2 and R 3 are each independently H, optionally substituted C 1-20 -alkyl or optionally substituted C 3-20 -cycloalkyl; R 4 and R 5 are each independently H or C 1-4 -alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl group; F is an acidic substituent; E is a basic substituent; m is 0 to 350; n is 1 to 75; v is 0 to 100; y is 1 to 100; b is 0, 1 or 2; s is 0 or 1; w is 1 to 4; and provided that at least one of R 4 and R 5 is H.

  本发明涉及一种组合物，包括：（i）一种抗微生物剂，包括聚合物双胍，单独或与从季铵化合物、单季铵杂环胺盐、脲衍生物、氨基化合物、咪唑衍生物、腈化合物、锡化合物或配合物、异噻唑啉-3-酮、噻唑衍生物、硝基化合物、碘化合物、醛释放剂、硫醇、三嗪衍生物、氧氮杂环和其衍生物、呋喃和其衍生物、羧酸及其盐和酯、酚及其衍生物、磺酰基衍生物、酰亚胺、硫酰胺、2-巯基吡啶-N-氧化物、唑类杀菌剂、链霉素、酰胺、氨基甲酸酯、吡啶衍生物、具有活性卤素基团的化合物和有机金属化合物中选择至少一种其他微生物活性成分组合而成；和（ii）式（1）的两性共聚物：其中：[A]为式（9）；[B]为式（10）；[C]为式（12）；[D]为式（13）；且X为式（11），其中[A]，[B]，[C]和[D]可以以任何顺序出现；T为可选的取代基；L，G和Z各自独立地为可选的取代连接基；R1，R2和R3各自独立地为H，可选的取代C1-20烷基或可选的取代C3-20环烷基；R4和R5各自独立地为H或C1-4烷基；q为15至1000；p为3至50；J为可选的取代的烃基；F为酸性取代基；E为碱性取代基；m为0至350；n为1至75；v为0至100；y为1至100；b为0、1或2；s为0或1；w为1至4；并且至少R4和R5中的一个为H。
• Substituted biaryl amides as C5A receptor modulators
  申请人：Gao Yang

  公开号：US20050096358A1

  公开（公告）日：2005-05-05

  Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了式I的取代联芳酰胺化合物。这些化合物是配体，可用于在体内或体外调节C5a受体活性，并且在治疗与人类、家畜伴侣动物和家畜动物中的C5a受体病理性激活相关的情况中特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的这种配体的使用方法。
• Substituted biaryl amides as C5a receptor modulators
  申请人：Gao Yang

  公开号：US20060178414A1

  公开（公告）日：2006-08-10

  Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5 a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5 a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式I的取代联苯酰胺化合物。这些化合物是配体，可用于体内或体外调节C5a受体活性，并且在治疗与人类、家养伴侣动物和家畜动物的病理性C5a受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的此类配体的使用方法。
• EP1487796A4
  申请人：——

  公开号：EP1487796A4

  公开（公告）日：2005-11-16