4-Acetylaminophenylphosphoric acid | 75966-18-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 4-Acetylaminophenylphosphoric acid
• 英文别名: (4-Acetamidophenyl) dihydrogen phosphate
• CAS: 75966-18-6
• 化学式: C₈H₁₀NO₅P
• 分子量: 231.145
• InChiKey: PSQWZQGQIUGIRU-UHFFFAOYSA-N

物化性质

• 密度：
  1.549±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• INORGANIC-ORGANIC HYBRID COMPOUNDS INCLUDING ORGANIC PLATINUM-CONTAINING ANIONS, FOR USE IN MEDICINE
  申请人：Karlsruher Institut fur Technologie

  公开号：US20210292353A1

  公开（公告）日：2021-09-23

  The present invention relates to inorganic-organic hybrid compounds for use in medicine or for use as medication, consisting of an inorganic metal cation and an organic platinum-containing cytostatic anion, in particular also a cisplatin derivative.

  本发明涉及用于医学或作为药物使用的无机-有机杂化化合物，包括无机金属阳离子和含有铂的细胞静止阴离子，特别是顺铂衍生物。
• ACETAMINOPHEN CONJUGATES, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Acorda Therapeutics, Inc.

  公开号：US20140243407A1

  公开（公告）日：2014-08-28

  Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to acetaminophen, reduced toxicity profile as compared to acetaminophen and an altered pharmacokinetic profile. Formulations comprising the conjugates are also provided, as are methods of using the conjugates and kits comprising the conjugates.

  提供了乙酰氨基酚结合物，其中乙酰氨基酚基团与第二基团共价连接。提供的结合物可能具有一个或多个优点，包括与乙酰氨基酚相比具有增加的水溶性，与乙酰氨基酚相比具有降低的毒性剖面和改变的药代动力学剖面。还提供了包含结合物的配方，以及使用结合物的方法和包含结合物的工具包。
• [EN] WATER-SOLUBLE ACETAMINOPHEN ANALOGS<br/>[FR] ANALOGUES D'ACÉTAMINOPHÈNE HYDROSOLUBLES
  申请人：NEUROGESX INC

  公开号：WO2009143295A1

  公开（公告）日：2009-11-26

  The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration. Methods of treating a disease or condition responsive to acetaminophen (such as fever and/or pain) using the acetaminophen prodrugs, as well as kits, unit dosages, and combinations with additional pharmaceutical agent(s) are also provided.

  本发明提供了水溶性的对乙酰氨基酚前药和配方，可适合于肌肉注射或静脉注射。使用对乙酰氨基酚前药治疗对乙酰氨基酚所响应的疾病或病症（如发热和/或疼痛）的方法，以及提供了配套工具、单元剂量和与其他药物剂型的组合。
• WATER-SOLUBLE ACETAMINOPHEN ANALOGS
  申请人：Acorda Therapeutics, Inc.

  公开号：US20160264605A1

  公开（公告）日：2016-09-15

  The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration. Methods of treating a disease or condition responsive to acetaminophen (such as fever and/or pain) using the acetaminophen prodrugs, as well as kits, unit dosages, and combinations with additional pharmaceutical agent(s) are also provided.

  本发明提供了水溶性的对乙酰氨基酚前药和制剂，适用于肌肉注射等途径。同时也提供了利用这些对乙酰氨基酚前药治疗对乙酰氨基酚反应性疾病或症状（如发热和/或疼痛）的方法，以及配套工具、单位剂量和与其他药物的联合使用。
• Water-soluble acetaminophen analogs
  申请人：Acorda Therapeutics, Inc.

  公开号：US10442826B2

  公开（公告）日：2019-10-15

  The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration. Methods of treating a disease or condition responsive to acetaminophen (such as fever and/or pain) using the acetaminophen prodrugs, as well as kits, unit dosages, and combinations with additional pharmaceutical agent(s) are also provided.

  本发明提供了适合肠外给药的水溶性对乙酰氨基酚原药和制剂。本发明还提供了使用对乙酰氨基酚原药治疗对乙酰氨基酚有反应的疾病或病症（如发热和/或疼痛）的方法，以及试剂盒、单位剂量和与其他药剂的组合。