3,5-bis(bromomethyl)phenylboronic acid | 443776-92-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-bis(bromomethyl)phenylboronic acid
• 英文别名: B-[3,5-Bis(bromomethyl)phenyl]boronic acid；[3,5-bis(bromomethyl)phenyl]boronic acid
• CAS: 443776-92-9
• 化学式: C₈H₉BBr₂O₂
• 分子量: 307.777
• InChiKey: WFXLKZPNPRXRJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-boronic acid-benzyl)-4,4’-bipyridinyl-1-ium bromide 、 3,5-bis(bromomethyl)phenylboronic acid 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以60%的产率得到
  参考文献：
  名称：

  Boronic acid-appended bis-viologens as a new family of viologen quenchers for glucose sensing

  摘要：

  A new family of boronic acid-appended viologen quenchers has been synthesized containing two viologen subunits in a single quencher moiety. Relative to the single viologen-based quenchers previously developed in our laboratory, the bis-viologen ortho-boronic acid (BoB) compounds, in combination with the fluorescent dye, HPTS, display greatly enhanced Stern-Volmer quenching constants and much greater signal modulation in response to glucose. The superior performance is realized at lower quencher-to-dye ratios than are required for the single-viologen systems. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2007.11.053