| 1228361-01-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• CAS: 1228361-01-0
• 化学式: C₄₉H₈₄O₆Si₂
• 分子量: 825.373
• InChiKey: IZGIQFKCRRDDAH-MEXFAFJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.99
• 重原子数：
  57.0
• 可旋转键数：
  15.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  63.22
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以98%的产率得到(3R,4R,5R,7R,8S,9S,10R,13R,14S,17R)-7-((benzyloxy)methoxy)-3-((tert-butyldimethylsilyl)oxy)-17-((2R,6S,Z)-7-((tert-butyldimethylsilyl)oxy)-6-methylhept-4-en-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-4-ol
  参考文献：
  名称：

  Second-generation synthesis of endogenous sperm-activating and attracting factor (SAAF) isolated from the ascidian Ciona intestinalis

  摘要：

  Stereoselective synthesis of the chemoattractant sperm-activating and attracting factor (SAAF), isolated from the eggs of the ascidian Ciona intestinalis, was achieved via reductive 1,3-transposition of an allylic alcohol and the axial opening of an epoxide as key steps. This second-generation synthesis improved the total yield of SAAF over that of the first-generation synthesis and provided a key intermediate for synthesizing molecular probes of SAAF. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.011
• 作为产物：
  描述：

  、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  Second-generation synthesis of endogenous sperm-activating and attracting factor (SAAF) isolated from the ascidian Ciona intestinalis

  摘要：

  Stereoselective synthesis of the chemoattractant sperm-activating and attracting factor (SAAF), isolated from the eggs of the ascidian Ciona intestinalis, was achieved via reductive 1,3-transposition of an allylic alcohol and the axial opening of an epoxide as key steps. This second-generation synthesis improved the total yield of SAAF over that of the first-generation synthesis and provided a key intermediate for synthesizing molecular probes of SAAF. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.011