N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-4-(2,2,2-trifluoro-1,1-dihydroxyethyl)benzamide | 1252579-25-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-4-(2,2,2-trifluoro-1,1-dihydroxyethyl)benzamide
• CAS: 1252579-25-1
• 化学式: C₂₂H₁₅F₃N₄O₆
• 分子量: 488.38
• InChiKey: NVHRXADVBXRPCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：ALEKSHUN MICHAEL N.

  公开号：US20110059962A1

  公开（公告）日：2011-03-10

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections, are also provided.
• [EN] TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS MODULATEURS DE FACTEUR DE TRANSCRIPTION ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PARATEK PHARM INNC

  公开号：WO2010124097A2

  公开（公告）日：2010-10-28

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections, are also provided.