(1,10-phenanthroline)[5-(triphenylphosphoniummethyl)salicylaldehyde benzoylhydrazonato] copper(II) chloride monohydrate ethanol | 1585165-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1,10-phenanthroline)[5-(triphenylphosphoniummethyl)salicylaldehyde benzoylhydrazonato] copper(II) chloride monohydrate ethanol
• CAS: 1585165-17-8
• 化学式: C₂H₆O*C₄₅H₃₄CuN₄O₂P*Cl*H₂O
• 分子量: 856.848
• InChiKey: LHLUASMWRSIGRU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 5-(triphenylphosphoniummethyl)salicylaldehyde benzoylhydrazone chloride monohydrate 、 copper(II) acetate monohydrate 以 乙醇 为溶剂， 反应 4.0h， 以69%的产率得到(1,10-phenanthroline)[5-(triphenylphosphoniummethyl)salicylaldehyde benzoylhydrazonato] copper(II) chloride monohydrate ethanol
  参考文献：
  名称：

  Copper complexes with phosphonium containing hydrazone ligand: Topoisomerase inhibition and cytotoxicity study

  摘要：

  Four new copper(II) complexes containing phosphonium substituted hydrazone (L) with the formulations [CuL]Cl(3), [Cu(phen)L]Cl(4), [Cu(bpy)L]Cl(5), [Cu(dbpy)L]Cl(6), (where L = doubly deprotonated hydrazone; phen = 1,10'-phenanthroline; bpy = 2,2'-bipyridine; dbpy = 5,5'-dimethyl-2,2'-bipyridine) have been synthesized. The compounds were characterized by elemental analysis, spectroscopic methods and in the case of crystalline products by X-ray crystallography. The cytotoxicity and topoisomerase I (topo I) inhibition activities of these compounds were studied. It is noteworthy that the addition of N,N-ligands to the copper(II) complex lead to the enhancement in the cytotoxicity of the compounds, especially against human prostate adenocarcinoma cell line (PC-3). Complex 4 exhibits the highest activity against PC-3 with the IC50 value of 3.2 mu M. The complexes can also inhibit topo I through the binding to DNA and the enzyme. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.02.049