3-bromo-5-t-butyl-8,8-dimethyl-7,8-dihydronaphthalen-2-ol | 362027-14-3

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 3-bromo-5-t-butyl-8,8-dimethyl-7,8-dihydronaphthalen-2-ol
• 英文别名: 3-bromo-5-tert-butyl-8,8-dimethyl-7H-naphthalen-2-ol
• CAS: 362027-14-3
• 化学式: C₁₆H₂₁BrO
• 分子量: 309.246
• InChiKey: JXPMWCLVJRDESV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-bromo-5-t-butyl-8,8-dimethyl-7,8-dihydronaphthalen-2-ol 、 溴甲苯 以to afford 0.23 g (100%) of the title compound as a yellow oil的产率得到7-benzyloxy-6-bromo-4-tert-butyl-1,1-dimethyl-1,2-dihydronaphthalene
  参考文献：
  名称：

  Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity

  摘要：

  式子1中符号的定义如规范所述，具有视黄醇激动剂、拮抗剂或负荷尔蒙样生物活性的化合物。

  公开号：

  US20040097733A1
• 作为产物：
  描述：

  3-bromo-5,8,8-trimethyl-7,8-dihydronaphthalen-2-ol 、 6-Bromo-4-t-butyl-7-methoxy-1,1-dimethyl-1,2-dihydronaphthalene 以to give 0.55 g (100%) of the title .compound as a yellow oil的产率得到3-bromo-5-t-butyl-8,8-dimethyl-7,8-dihydronaphthalen-2-ol
  参考文献：
  名称：

  Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity

  摘要：

  式子1中符号的定义如规范所述，具有视黄醇激动剂、拮抗剂或负荷尔蒙样生物活性的化合物。

  公开号：

  US20040097733A1

文献信息

• 7-[(7-ALKOXY)-CHROM-3-EN-6-YL]-HEPTATRIENOIC ACID AND 7-[(3-ALKOXY)-5,6-DIHYDRONAPHTHALEN-2-YL]-HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY
  申请人：Beard L. Richard

  公开号：US20050096380A1

  公开（公告）日：2005-05-05

  Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.

  化合物的公式为其中变量的含义在规范中定义，能够降低糖尿病哺乳动物的血清葡萄糖水平，而不会产生不良副作用，如短暂增加甘油三酯水平和降低血清甲状腺素水平。
• 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
  申请人：Beard Richard L.

  公开号：US06887896B1

  公开（公告）日：2005-05-03

  Compounds of the formula where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.

  化合物的公式为，在规范中定义了含义的变化，能够降低糖尿病哺乳动物的血清葡萄糖水平，而不会出现短暂增加甘油三酯水平和降低血清甲状腺素水平等不良副作用。
• Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, a pyridyl group and an alkyl group, having retinoid-like biological activity
  申请人：Allergan, Inc.

  公开号：US07026487B2

  公开（公告）日：2006-04-11

  Compounds of the formula where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity.

  式中符号如规范所定义的化合物具有视黄醛激动剂、拮抗剂或负激素样生物活性。
• AMINES SUBSTITUTED WITH A DIHYDRONAPHTHALENYL, CRHOMENYL, OR THIOCHROMENYL GROUP, AN ARYL OR HETEROARYL GROUP AND AN ALKYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY
  申请人：Allergan Sales, Inc.

  公开号：EP1265848A2

  公开（公告）日：2002-12-18
• US6613917B1
  申请人：——

  公开号：US6613917B1

  公开（公告）日：2003-09-02