2-cyclopropyl-4-methylpyrimidine-5-carboxylic acid pyridazin-4-yl methylamide | 1335108-38-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-cyclopropyl-4-methylpyrimidine-5-carboxylic acid pyridazin-4-yl methylamide
• 英文别名: 2-Cyclopropyl-4-methyl-pyrimidine-5-carboxylic acid pyridazin-4-yl methyl amide；2-cyclopropyl-N,4-dimethyl-N-pyridazin-4-ylpyrimidine-5-carboxamide
• CAS: 1335108-38-7
• 化学式: C₁₄H₁₅N₅O
• 分子量: 269.306
• InChiKey: XMJRTJXLETZZQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-cyclopropyl-4-methyl-pyrimidine-5-carboxylic acid 、 N-methylaminopyridazine 在 4-二甲氨基吡啶 、 N,N'-二异丙基碳二亚胺 、 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以39%的产率得到2-cyclopropyl-4-methylpyrimidine-5-carboxylic acid pyridazin-4-yl methylamide
  参考文献：
  名称：

  [EN] PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
  [FR] COMPOSÉS DE PYRIDAZINE POUR LUTTER CONTRE LES RAVAGEURS INVERTÉBRÉS

  摘要：

  本发明涉及公式（I）或（II）的吡嗪化合物及其盐，N-氧化物及其盐，其中基团A为公式（A），其中#表示连接到公式（I）或（II）的其余部分的点，其中A1为N或C-RA1，A2为N或C-RA2，A3为N或C-RA3，A4为N或C-RA4，A5为N或C-RA5，前提是A1、A2、A3、A4或A5中的一个或两个变量为N；RA1、RA5（如存在）为H、卤素、CN、NO2、C1-C6烷基、C1-C6卤代烷基等；RA2、RA4（如存在）为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；RA3（如存在）为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；其中W为N或C-Rw，V为N或C-Rv，前提是W或V中的一个为N；Rt和Rw（如存在）为H、卤素、甲基、C1卤代烷基等；Ru和Rv（如存在）为H、卤素、C1-C4烷基、C1-C3卤代烷基等；X1为S、O或NR1a，其中R1a为H、C1-C10烷基等；X2为OR2a、NR2bR2c、S（0）mR2d，其中m为0、1或2，R2a为C1-C4烷基、C1-C4卤代烷基等，R2b、R2c为H、C1-C4烷基、C1-C4卤代烷基等，或R2b和R2c与它们所结合的氮原子形成杂环，R2d为C1-C4烷基、C1-C4卤代烷基、C3-C6环烷基等；R1为H、CN、C1-C10烷基等。本发明还涉及一种控制无脊椎动物害虫的方法，一种保护植物繁殖材料和/或从中生长的植物的方法，包括至少一种本发明化合物的植物繁殖材料，一种用于治疗或保护动物免受寄生虫感染的方法，以及一种包含至少一种本发明化合物的农业组合物。

  公开号：

  WO2011117286A1

文献信息

• Pyridazine Compounds For Controlling Invertebrate Pests
  申请人：Le Vezouet Ronan

  公开号：US20130012380A1

  公开（公告）日：2013-01-10

  The present invention relates to pyridazine compounds of formulae I or II and the salts thereof, the N-oxides thereof and the salts of the N-oxides thereof, where the radical A is of the formula A, wherein # denotes the point of attachment to the remainder of formulae I or II, and wherein A 1 is N or C—R A1 , A 2 is N or C—R A2 , A 3 is N or C—R A3 , A 4 is N or C—R A4 and A 5 is N or C—R A5 , provided that one or two of the variables A 1 , A 2 , A 3 , A 4 or A 5 is N; R A1 , R A5 , if present, are H, halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl and the like; R A2 , R A4 , if present, are H, halogen, CN, NO 2 , C 1 -C 10 -alkyl, C 1 -C 10 -haloalkyl and the like; R A3 , if present, is H, halogen, CN, NO 2 , C 1 -C 10 -alkyl, C 1 -C 10 -haloalkyl and the like; where W is N or C—R W and V is N or C—R V , provided that one of the variables W or V is N; R t and R w , if present, are H, halogen, methyl, C 1 -haloalkyl and the like; R u and R v , if present, are H, halogen, C 1 -C 4 -alkyl, C 1 -C 3 -haloalkyl and the like; X 1 is S, O or NR 1a , wherein R 1a is H, C 1 -C 10 -alkyl and the like; X 2 is OR 2a , NR 2b R 2c , S(O) m R 2d , wherein m is 0, 1 or 2, R 2a is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and the like, R 2b , R 2c are H, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and the like, or R 2b and R 2c together with the nitrogen atom to which they are bound form a heterocycle, and R 2d is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl and the like; and R 1 is H, CN, C 1 -C 10 -alkyl and the like. The present invention further relates to a method for controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites and to an agricultural composition containing at least one compound according to the present invention.

  本发明涉及公式I或II的吡嗪化合物及其盐，其N-氧化物及其盐，其中基团A为公式A的形式，其中#表示连接到公式I或II其余部分的点，其中A1为N或C-RA1，A2为N或C-RA2，A3为N或C-RA3，A4为N或C-RA4，A5为N或C-RA5，前提是A1、A2、A3、A4或A5中的一个或两个变量为N；RA1、RA5（如果存在）为H、卤素、CN、NO2、C1-C6烷基、C1-C6卤代烷基等；RA2、RA4（如果存在）为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；RA3（如果存在）为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；其中W为N或C-RW，V为N或C-RV，前提是W或V中的一个变量为N；Rt和Rw（如果存在）为H、卤素、甲基、C1卤代烷基等；Ru和Rv（如果存在）为H、卤素、C1-C4烷基、C1-C3卤代烷基等；X1为S、O或NR1a，其中R1a为H、C1-C10烷基等；X2为OR2a、NR2bR2c、S（O）mR2d，其中m为0、1或2，R2a为C1-C4烷基、C1-C4卤代烷基等，R2b、R2c为H、C1-C4烷基、C1-C4卤代烷基等，或R2b和R2c与它们所连接的氮原子形成杂环，而R2d为C1-C4烷基、C1-C4卤代烷基、C3-C6环烷基等；R1为H、CN、C1-C10烷基等。本发明还涉及一种控制无脊椎动物害虫的方法，一种保护植物繁殖材料和/或其生长的植物的方法，包括至少一种本发明化合物的植物繁殖材料，一种用于治疗或保护动物免受寄生虫感染或感染的方法以及一种包含至少一种本发明化合物的农业组合物。
• Pyridazine compounds for controlling invertebrate pests
  申请人：Le Vezouet Ronan

  公开号：US09040537B2

  公开（公告）日：2015-05-26

  The present invention relates to pyridazine compounds of formulae I or II and the salts thereof, the N-oxides thereof and the salts of the N-oxides thereof, where the radical A is of the formula A, wherein # denotes the point of attachment to the remainder of formulae I or II, and wherein A1 is N or C—RA1, A2 is N or C—RA2, A3 is N or C—RA3, A4 is N or C—RA4 and A5 is N or C—RA5, provided that one or two of the variables A1, A2, A3, A4 or A5 is N; RA1, RA5, if present, are H, halogen, CN, NO2, C1-C6-alkyl, C1-C6-haloalkyl and the like; RA2, RA4, if present, are H, halogen, CN, NO2, C1-C10-alkyl, C1-C10-haloalkyl and the like; RA3, if present, is H, halogen, CN, NO2, C1-C10-alkyl, C1-C10-haloalkyl and the like; where W is N or C—RW and V is N or C—RV, provided that one of the variables W or V is N; Rt and Rw, if present, are H, halogen, methyl, C1-haloalkyl and the like; Ru and Rv, if present, are H, halogen, C1-C4-alkyl, C1-C3-haloalkyl and the like; X1 is S, O or NR1a, wherein R1a is H, C1-C10-alkyl and the like; X2 is OR2a, NR2bR2c, S(O)mR2d, wherein m is 0, 1 or 2, R2a is C1-C4-alkyl, C1-C4-haloalkyl and the like, R2b, R2c are H, C1-C4-alkyl, C1-C4-haloalkyl and the like, or R2b and R2c together with the nitrogen atom to which they are bound form a heterocycle, and R2d is C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl and the like; and R1 is H, CN, C1-C10-alkyl and the like. The present invention further relates to a method for controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites and to an agricultural composition containing at least one compound according to the present invention.

  本发明涉及公式I或II的吡啶嗪化合物及其盐，其N-氧化物及其N-氧化物的盐，其中基团A为公式A的形式，其中#表示连接到公式I或II的其余部分的点，其中A1为N或C-RA1，A2为N或C-RA2，A3为N或C-RA3，A4为N或C-RA4，A5为N或C-RA5，前提是A1、A2、A3、A4或A5中的一个或两个变量为N；如果存在，则RA1、RA5为H、卤素、CN、NO2、C1-C6烷基、C1-C6卤代烷基等；如果存在，则RA2、RA4为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；如果存在，则RA3为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；其中W为N或C-RW，V为N或C-RV，前提是W或V中的一个变量为N；如果存在，则Rt和Rw为H、卤素、甲基、C1卤代烷基等；如果存在，则Ru和Rv为H、卤素、C1-C4烷基、C1-C3卤代烷基等；X1为S、O或NR1a，其中R1a为H、C1-C10烷基等；X2为OR2a、NR2bR2c、S（O）mR2d，其中m为0、1或2，R2a为C1-C4烷基、C1-C4卤代烷基等，R2b、R2c为H、C1-C4烷基、C1-C4卤代烷基等，或R2b和R2c与它们连接的氮原子形成杂环，R2d为C1-C4烷基、C1-C4卤代烷基、C3-C6环烷基等；R1为H、CN、C1-C10烷基等。本发明还涉及一种控制无脊椎动物害虫的方法，一种保护植物繁殖材料和/或从中生长的植物的方法，包括至少一种本发明化合物的植物繁殖材料，一种用于治疗或保护动物免受寄生虫感染的方法，以及一种含有至少一种本发明化合物的农业组合物。
• PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
  申请人：BASF SE

  公开号：EP2550264A1

  公开（公告）日：2013-01-30
• US9040537B2
  申请人：——

  公开号：US9040537B2

  公开（公告）日：2015-05-26
• [EN] PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS<br/>[FR] COMPOSÉS DE PYRIDAZINE POUR LUTTER CONTRE LES RAVAGEURS INVERTÉBRÉS
  申请人：BASF SE

  公开号：WO2011117286A1

  公开（公告）日：2011-09-29

  The present invention relates to pyridazine compounds of formulae (I) or (II) and the salts thereof, the N-oxides thereof and the salts of the N-oxides thereof, where the radical A is of the formula (A), wherein # denotes the point of attachment to the remainder of formulae (I) or (I I), and wherein A1 is N or C-RA1, A2 is N or C-RA2, A3 is N or C-RA3, A4 is N or C-RA4 and A5 is N or C-RA5, provided that one or two of the variables A1, A2, A3, A4 or A5 is N; RA1, RA5, if present, are H, halogen, CN, NO2, C1-C6-alkyl, C1-C6-haloalkyl and the like; RA2, RA4, if present, are H, halogen, CN, NO2, C1-C10-alkyl, C1-C10-haloalkyl and the like; RA3, if present, is H, halogen, CN, NO2, C1-C10-alkyl, C1-C10-haloalkyl and the like; where W is N or C-Rw and V is N or C-Rv, provided that one of the variables W or V is N; Rt and Rw, if present, are H, halogen, methyl, C1-haloalkyl and the like; Ru and Rv, if present, are H, halogen, C1-C4-alkyl, C1-C3-haloalkyl and the like; X1 is S, O or NR1a, wherein R1a is H, C1-C10-alkyl and the like; X2 is OR2a, NR2bR2c, S(0)mR2d, wherein m is 0, 1 or 2, R2a is C1-C4-alkyl, C1-C4-haloalkyl and the like, R2b, R2c are H, C1-C4-alkyl, C1-C4-haloalkyl and the like, or R2b and R2c together with the nitrogen atom to which they are bound form a heterocycle, and R2d is C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl and the like; and R1 is H, CN, C1-C10-alkyl and the like. The present invention further relates to a method for controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites and to an agricultural composition containing at least one compound according to the present invention.

  本发明涉及公式（I）或（II）的吡嗪化合物及其盐，N-氧化物及其盐，其中基团A为公式（A），其中#表示连接到公式（I）或（II）的其余部分的点，其中A1为N或C-RA1，A2为N或C-RA2，A3为N或C-RA3，A4为N或C-RA4，A5为N或C-RA5，前提是A1、A2、A3、A4或A5中的一个或两个变量为N；RA1、RA5（如存在）为H、卤素、CN、NO2、C1-C6烷基、C1-C6卤代烷基等；RA2、RA4（如存在）为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；RA3（如存在）为H、卤素、CN、NO2、C1-C10烷基、C1-C10卤代烷基等；其中W为N或C-Rw，V为N或C-Rv，前提是W或V中的一个为N；Rt和Rw（如存在）为H、卤素、甲基、C1卤代烷基等；Ru和Rv（如存在）为H、卤素、C1-C4烷基、C1-C3卤代烷基等；X1为S、O或NR1a，其中R1a为H、C1-C10烷基等；X2为OR2a、NR2bR2c、S（0）mR2d，其中m为0、1或2，R2a为C1-C4烷基、C1-C4卤代烷基等，R2b、R2c为H、C1-C4烷基、C1-C4卤代烷基等，或R2b和R2c与它们所结合的氮原子形成杂环，R2d为C1-C4烷基、C1-C4卤代烷基、C3-C6环烷基等；R1为H、CN、C1-C10烷基等。本发明还涉及一种控制无脊椎动物害虫的方法，一种保护植物繁殖材料和/或从中生长的植物的方法，包括至少一种本发明化合物的植物繁殖材料，一种用于治疗或保护动物免受寄生虫感染的方法，以及一种包含至少一种本发明化合物的农业组合物。