N-(2-mercaptophenyl)propionamide | 1199-16-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-mercaptophenyl)propionamide
• 英文别名: 2-Propionylamino-thiophenol；N-(2-sulfanylphenyl)propanamide
• CAS: 1199-16-2
• 化学式: C₉H₁₁NOS
• 分子量: 181.258
• InChiKey: UKXRXACWHOSCPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  30.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-ethoxycarbonyl-6-methyl-1,3-dipropionyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 、 2-氨基苯硫醇 以 四氢呋喃 为溶剂， 以73%的产率得到N-(2-mercaptophenyl)propionamide
  参考文献：
  名称：

  N 1，N 3-二酰基-3,4-二氢嘧啶-2（1 H）-ones：中性酰基转移试剂

  摘要：

  易于获得的N 1，N 3-二酰基3,4-二氢嘧啶-2（1 H）-一有效地酰化氨，伯胺和仲胺，从而以良好或优异的收率提供伯，仲和叔酰胺。通过在中性介质中进行反应，易于分离产物，回收无害副产物和进行转化的化学选择性，证明了该方法的广泛适用性。

  DOI：

  10.1016/j.tet.2009.10.037

文献信息

• Chemoselective Acylation of Amines in Aqueous Media
  作者：Sarala Naik、Gitalee Bhattacharjya、Bandana Talukdar、Bhisma K. Patel

  DOI：10.1002/ejoc.200300620

  日期：2004.3

  Amines are efficiently acylated by both cyclic and acyclic anhydrides by dissolving them in an aqueous medium with the help of a surfactant, sodium dodecyl sulfate (SDS). Cyclic and acyclic anhydrides react with equal ease with an amine, and amines with various stereo-electronic factors react at the same rates with an anhydride. Chemoselective acylation of amines in the presence of phenols and thiols

  通过在表面活性剂十二烷基硫酸钠 (SDS) 的帮助下将胺溶解在水性介质中，胺被环状酸酐和无环酸酐有效地酰化。环状和无环酸酐与胺反应同样容易，具有各种立体电子因子的胺与酸酐以相同的速率反应。已经实现了在酚类和硫醇存在下胺的化学选择性酰化以及在酚存在下硫醇的化学选择性酰化。反应过程中不使用酸性或碱性试剂。分离酰化产物不需要色谱分离。在中性水性介质中反应，产物容易分离，副产物无害，使本方法成为一种绿色化学过程。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
• Substituted Fused Pyrimidine Compounds
  申请人：Advinus Therapeutics Private Limited

  公开号：US20150087643A1

  公开（公告）日：2015-03-26

  The present invention discloses substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, solvates, pharmaceutically acceptable salts, or pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity; the compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by antagonism of the adenosine receptor, such as asthma, chronic obstructive pulmonary disorder, angiogenesis, pulmonary fibrosis, emphysema, allergic diseases, inflammation, reperfusion injury, myocardial ischemia, atherosclerosis, hypertension, congestive heart failure, retinopathy, diabetes mellitus, obesity, inflammatory gastrointestinal tract disorders, and/or autoimmune diseases.

  本发明揭示了式（I）的取代融合嘧啶化合物，它们的互变异构体、多晶形、立体异构体、溶剂化物、药学上可接受的盐或含有它们的制药组合物以及治疗通过腺苷受体（AR）活性介导的疾病和病症的方法；本发明中的化合物在治疗、预防或抑制疾病和疾病方面有用，这些疾病和疾病可能通过拮抗腺苷受体而容易改善，例如哮喘、慢性阻塞性肺疾病、血管生成、肺纤维化、肺气肿、过敏性疾病、炎症、再灌注损伤、心肌缺血、动脉粥样硬化、高血压、充血性心力衰竭、视网膜病变、糖尿病、肥胖、炎症性肠道疾病和/或自身免疫性疾病。
• Solid phase synthesis of benzothiazolyl compounds
  作者：Spyros Mourtas、Dimitrios Gatos、Kleomenis Barlos

  DOI：10.1016/s0040-4039(01)00109-5

  日期：2001.3

  2-Aminobenzenethiol, bound through its thiol function to the 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)- and 4-methoxytrityl (Mmt)-resins, was acylated at the amino-function by aliphatic and aromatic acids. The obtained 2-N-acylaminobenzenethiols were cleaved from the resin by treatment with trifluoroacetic acid solutions in dichloromethane. The 2-N-acyl-aminobenzenethiols released from the resin were cyclised to the corresponding 2-substituted benzothiazoles, by standing in a solution of dithiothreitol in DMF or methanol for 1-3 h at room temperature. (C) 2001 Elsevier Science Ltd. All rights reserved.