1-{2-[4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-quinazolin-2-yl]-1-methyl-1H-benzoimidazol-5-yl}-ethanone | 1125484-38-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-{2-[4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-quinazolin-2-yl]-1-methyl-1H-benzoimidazol-5-yl}-ethanone
• 英文别名: 1-[1-Methyl-2-[4-(4-propan-2-ylphenyl)-6-prop-2-ynoxyquinazolin-2-yl]benzimidazol-5-yl]ethanone
• CAS: 1125484-38-9
• 化学式: C₃₀H₂₆N₄O₂
• 分子量: 474.562
• InChiKey: QGMCGANIMOLDRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] PHENYLISOQUINOLINE AND PHENYLQUINAZOLINE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES<br/>[FR] PHÉNYLISOQUINOLINE ET DÉRIVÉS DE PHÉNYLQUINAZOLINE DESTINÉS AU TRAITEMENT DE MALADIES OSSEUSES
  申请人：NOVARTIS AG

  公开号：WO2009027475A1

  公开（公告）日：2009-03-05

  The present invention relates to substituted phenylisoquinoline and phenylquinazoline derivatives and to their pharmaceutical uses in preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.

  本发明涉及替代苯基异喹啉和苯基喹啉衍生物，以及它们在预防或治疗与钙流失或吸收增加有关的骨病症，或者在骨骼中骨形成和钙固定受到刺激是可取的情况下的药用。
• Phenylisoquinoline and Phenylquinazoline Derivatives
  申请人：Beerli Rene

  公开号：US20090074791A1

  公开（公告）日：2009-03-19

  The present invention relates to substituted phenylisoquinoline and phenylquinazoline derivatives and to their pharmaceutical uses in preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.

  本发明涉及取代苯基异喹啉和苯基喹唑啉衍生物及其在预防或治疗与增加的钙流失或吸收有关的骨病条件或在骨骼中刺激骨形成和钙固定是有益的药物用途方面的应用。
• PHENYLISOQUINOLINE AND PHENYLQUINAZOLINE DERIVATIVES FOR THE TREATMENT OF BONE DISEASES
  申请人：Novartis AG

  公开号：EP2197872A1

  公开（公告）日：2010-06-23