2-Amino-4-methoxy-5-chlor-pyrimidin | 5750-77-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Amino-4-methoxy-5-chlor-pyrimidin
• 英文别名: 5-chloro-4-methoxy-pyrimidin-2-ylamine；5-chloro-4-methoxy-2-Pyrimidinamine；5-chloro-4-methoxypyrimidin-2-amine
• CAS: 5750-77-6
• 化学式: C₅H₆ClN₃O
• 分子量: 159.575
• InChiKey: YNUMARLBWZFUPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] INHIBITORS OF CYCLIN-DEPENDENT KINASES<br/>[FR] INHIBITEURS DE KINASES DÉPENDANTES DES CYCLINES
  申请人：KINNATE BIOPHARMA INC

  公开号：WO2021011796A1

  公开（公告）日：2021-01-21

  Provided herein are compounds which are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

  本文提供了一些抑制细胞周期依赖性激酶（CDKs）的化合物，包括这些化合物的药物组合物，以及利用这些化合物治疗疾病的方法。
• Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
  申请人：UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

  公开号：US10058516B2

  公开（公告）日：2018-08-28

  The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.

  本发明涉及使用核苷类似物治疗或预防病毒感染的化合物、方法和组合物。具体地说，本发明提供了无环柔性核苷类似物的设计和合成，这些类似物具有更高的灵活性和改变其构象结构的能力，从而提供了更高的抗病毒活性潜力，从而抑制多种冠状病毒。
• Inhibitors of cyclin-dependent kinases
  申请人：Kinnate Biopharma Inc.

  公开号：US10894788B2

  公开（公告）日：2021-01-19

  Provided herein are inhibitors of cyclin-dependent kinases (CDKs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

  本文提供了细胞周期蛋白依赖性激酶（CDK）的抑制剂、包含所述化合物的药物组合物以及使用所述化合物治疗疾病的方法。
• DESIGN SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXIMER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY
  申请人：University of Maryland, Baltimore County

  公开号：EP3250564A2

  公开（公告）日：2017-12-06
• DESIGN, SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXMIER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY
  申请人：UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

  公开号：US20180015052A1

  公开（公告）日：2018-01-18

  The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.