6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-5-methoxy-pyridine-2-carboxaldehyde | 329217-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-5-methoxy-pyridine-2-carboxaldehyde
• 英文别名: 6-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphth-2-yl)-5-methoxy-pyridine-2-carboxaldehyde；5-methoxy-6-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)pyridine-2-carbaldehyde
• CAS: 329217-76-7
• 化学式: C₂₂H₂₇NO₂
• 分子量: 337.462
• InChiKey: PIGOWCQTROGVIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-溴-5-甲氧基吡啶醛 、 3,5,5,8,8-五甲基-5,6,7,8-四氢萘-2-硼酸 、 potassium carbonate 在 四(三苯基膦)钯 氩 、 水 、 Brine 、 magnesium sulfate 、 silica gel 作用下， 以 乙二醇二甲醚 、 水 、 乙酸乙酯 为溶剂， 反应 24.0h， 以to give 603 mg (75% yield) of 6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphth-2-yl)-5-methoxy-pyridine-2-carboxaldehyde的产率得到6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-5-methoxy-pyridine-2-carboxaldehyde
  参考文献：
  名称：

  Imidazolidinedione derivatives for the treatment of diabetes and other diseases

  摘要：

  本发明涉及某些公式（I）的取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病方面具有用途，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，例如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或普遍癌症；以及炎症，例如骨关节炎、类风湿性关节炎、克罗恩病或炎症性肠病。

  公开号：

  US06974826B2

文献信息

• Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia
  申请人：——

  公开号：US20030083357A1

  公开（公告）日：2003-05-01

  The present invention relates to compounds of Formula (I) which may be useful in the treatment of diseases, such as, metabolic disorders, dyslipidemia and/or hyperchloesterolemia: 1

  本发明涉及Formula (I)的化合物，可能在治疗疾病，如代谢紊乱、血脂异常和/或高胆固醇血症方面有用：
• Substituted heterocycles for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20060004059A1

  公开（公告）日：2006-01-05

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及公式（I）的某些取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病中有用，例如2型糖尿病，脂肪细胞分化，不受控制的增殖（如淋巴瘤，霍奇金病，白血病，乳腺癌，前列腺癌或癌症总体）和炎症（如骨关节炎，类风湿性关节炎，克罗恩病或炎性肠病）。
• Thiazolidinedione derivatives for the treatment of diabetes and other diseases
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：US20030153606A1

  公开（公告）日：2003-08-14

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease. 1

  本发明涉及公式(I)的某些取代杂环，其在治疗与脂质和碳水化合物代谢相关的疾病方面有用，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，例如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般的癌症；以及炎症，例如骨关节炎、风湿性关节炎、克隆氏病或炎性肠病。
• Heterocyclic derivatives for the treatment of diabetes and other diseases
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：US06515003B1

  公开（公告）日：2003-02-04

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及一些配有取代基的杂环化合物（I）的使用，该化合物在治疗与脂质和碳水化合物代谢相关的疾病方面具有用途，例如2型糖尿病，脂肪细胞分化，无法控制的增殖，例如淋巴瘤，霍奇金病，白血病，乳腺癌，前列腺癌或普遍的癌症；以及炎症，例如骨关节炎，类风湿性关节炎，克罗恩病或炎性肠病。
• Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes
  申请人：Incyte San Diego Incorporated

  公开号：EP1593677A2

  公开（公告）日：2005-11-09

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatiod arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及某些取代的式(I)杂环，可用于治疗与脂质和碳水化合物代谢有关的疾病，如 2 型糖尿病、脂肪细胞分化、增殖失控，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般癌症；以及炎症，如骨关节炎、风湿性关节炎、克罗恩病或炎症性肠病。