4-mercapto-benzoic acid hydrazide | 101870-19-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-mercapto-benzoic acid hydrazide
• 英文别名: 4-Mercapto-benzoesaeure-hydrazid；4-sulfanylbenzohydrazide；(Thio)benzhydrazide
• CAS: 101870-19-3
• 化学式: C₇H₈N₂OS
• mdl: MFCD18204788
• 分子量: 168.219
• InChiKey: DXXLPHXYHMSHLP-UHFFFAOYSA-N

物化性质

• 熔点：
  152-153 °C
• 密度：
  1.298±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-mercapto-benzoic acid hydrazide 在 吡啶 、 甲醇 、 碘 、 溶剂黄146 作用下， 生成 4,4'-disulfanediyl-di-benzoic acid bis-(2,4-dichloro-benzylidenehydrazide)
  参考文献：
  名称：

  Hydrazine Derivatives. I. Benzalthio- and Bisbenzaldithio-Salicylhydrazides

  摘要：

  DOI：

  10.1021/jo50016a019
• 作为产物：
  描述：

  4-巯基苯甲酸 在 硫酸 、 肼 作用下， 以 甲醇 、 氯仿 、 水 为溶剂， 生成 4-mercapto-benzoic acid hydrazide
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS FOR IDENTIFYING AND/OR QUANTIFYING CARBONYLATED BIOMOLECULES
  [FR] COMPOSÉS ET PROCÉDÉS POUR L'IDENTIFICATION ET/OU LA QUANTIFICATION DE BIOMOLÉCULES CARBONYLÉES

  摘要：

  本发明提供了一种利用本发明化合物对羰基化生物分子进行衍生化、鉴定和/或定量的方法。本发明提供了一种利用这些化合物分析氧化生物分子物种（如肽、蛋白质和脂质）的方法。这种方法有利地实现了羰基化样品的同时衍生化、定量和富集，并且完全适用于质谱分析。

  公开号：

  WO2012152943A1

文献信息

• KINASE INHIBITORS
  申请人：Dong Qing

  公开号：US20090247554A1

  公开（公告）日：2009-10-01

  Compounds are provided for use with kinases that comprise (I), (II), (III), (IV): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  提供了与包含(I)、(II)、(III)、(IV)的激酶一起使用的化合物：其中变量如本文所定义。还提供了包括这些化合物的药物组合物、工具包和制造物品；用于制备这些化合物的方法和中间体；以及使用这些化合物的方法。
• Oxidized lipid detection
  申请人：KRATOS ANALYTICAL LIMITED

  公开号：US10948502B2

  公开（公告）日：2021-03-16

  The present invention is concerned with a method of extracting oxidized lipids from a lipid solution, the method comprising (a) a derivatisation step, comprising contacting a derivatisation agent with the lipid solution such that aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids, if present in the lipid solution, are derivatised to include an anionic group, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles capture anionic-group containing oxidised lipids. The invention also includes a method of extracting aldehydic oxidized phospholipids from a lipid solution, the method comprising (a) a derivatisation step, comprising introduction of a anionic group to aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids in the lipid solution, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles bind anionic-group containing oxidised lipids.

  本发明涉及一种从脂质溶液中提取氧化脂质的方法，该方法包括(a)衍生化步骤，包括将衍生化剂与脂质溶液接触，使脂质溶液中存在的醛氧化脂质和/或α、(b) 氧化脂质捕获步骤，其中纳米颗粒与脂质溶液接触，纳米颗粒捕获含有阴离子基团的氧化脂质。本发明还包括一种从脂溶液中提取醛氧化磷脂的方法，该方法包括：(a) 衍生化步骤，包括向脂溶液中的醛氧化脂和（或）α，β-不饱和氧化脂中引入阴离子基团；(b) 氧化脂捕获步骤，其中纳米颗粒与脂溶液接触，纳米颗粒结合含有阴离子基团的氧化脂。
• Gialdi et al., Farmaco, Edizione Scientifica, 1959, vol. 14, p. 216,232
  作者：Gialdi et al.

  DOI：——

  日期：——
• OXIDIZED LIPID DETECTION
  申请人：Kratos Analytical Limited

  公开号：EP3105597B1

  公开（公告）日：2020-11-18
• [EN] OXIDIZED LIPID DETECTION<br/>[FR] DÉTECTION DE LIPIDES OXYDÉS
  申请人：KRATOS ANALYTICAL LTD

  公开号：WO2015121627A1

  公开（公告）日：2015-08-20

  The present invention is concerned with a method of extracting oxidized lipids from a lipid solution, the method comprising (a) a derivatisation step, comprising contacting a derivatisation agent with the lipid solution such that aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids, if present in the lipid solution, are derivatised to include an anionic group, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles capture anionic-group containing oxidised lipids. The invention also includes a method of extracting aldehydic oxidized phospholipids from a lipid solution, the method comprising (a) a derivatisation step, comprising introduction of a anionic group to aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids in the lipid solution, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles bind anionic-group containing oxidised lipids.