名称:
Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus
摘要:
A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described. (C) 2007 Elsevier Ltd. All rights reserved.
DOI:
10.1016/j.bmcl.2007.07.040