2,6-Dichlor-3-methylbenzaldehyd | 60611-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-Dichlor-3-methylbenzaldehyd
• 英文别名: 2,6-Dichloro-3-methylbenzaldehyde
• CAS: 60611-23-6
• 化学式: C₈H₆Cl₂O
• 分子量: 189.041
• InChiKey: MSZRBMZQLCUACG-UHFFFAOYSA-N

物化性质

• 沸点：
  260.4±35.0 °C(Predicted)
• 密度：
  1.338±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-Dichlor-3-methylbenzaldehyd 、 乙硫醇 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 水 为溶剂， 反应 5.0h， 生成 、
  参考文献：
  名称：

  Synthesis and evaluation of 1-(benzo[b]thiophen-2-yl)ethanone analogues as novel anti-osteoporosis agents acting on BMP-2 promotor

  摘要：

  A novel series of 1-(benzo[b]thiophen-2-yl)ethanone analogues were prepared and evaluated for enhancing BMP-2 expression. Compounds 1-5, 7, 8, 12, 13 and 16, with upregulation rate values of 35.6%, 27.9%, 39.8%, 32.0%, 37.1%, 30.2%, 28.0%, 33.5%, 22.8% and 27.3% in vitro, respectively, at a concentration of 4 mu M, exhibited potent effect for enhancing BMP-2 expression. We also found that compounds 1 and 12 produced a dose-dependent increase on bone histology and histomorphometry, and effectively reduced bone defects induced by ovariectomy in an ovariectomized rat model (OVX). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.118

文献信息

• Phenylalanine derivatives
  申请人：Sagi Kazuyuki

  公开号：US20050101779A1

  公开（公告）日：2005-05-12

  The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to α4 integrin and therapeutic agents for various diseases concerning α4 integrin.

  本发明涉及以下苯丙氨酸衍生物或其类似物，具有对α4整合素的拮抗活性以及与α4整合素有关的各种疾病的治疗剂。
• NEW PHENYLALANINE DERIVATIVES
  申请人：MAKINO Shingo

  公开号：US20120253041A1

  公开（公告）日：2012-10-04

  Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.

  指定的苯丙氨酸衍生物及其类似物具有对α4整合素的拮抗作用。它们被用作治疗涉及α4整合素的各种疾病的治疗剂。
• New phenylalanine derivatives
  申请人：Makino Shingo

  公开号：US20060223836A1

  公开（公告）日：2006-10-05

  Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.

  指定的苯丙氨酸衍生物及其类似物具有对α4整合素的拮抗活性。它们用作涉及α4整合素的各种疾病的治疗剂。
• NOVEL PHENYLALANINE DERIVATIVES
  申请人：Ajinomoto Co., Inc.

  公开号：EP1288205A1

  公开（公告）日：2003-03-05

  Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.

  特定的苯丙氨酸衍生物及其类似物具有拮抗 α4 整合素的活性。它们可用作治疗与α4整合素有关的各种疾病的药物。
• NOVEL PHENYLALANINE DERIVATIVE
  申请人：Ajinomoto Co., Inc.

  公开号：EP1477482B1

  公开（公告）日：2010-04-14