2-fluoro-4-chlorobenzylsulfonyl chloride | 1308384-53-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluoro-4-chlorobenzylsulfonyl chloride
• 英文别名: (4-Chloro-2-fluorophenyl)methanesulfonyl chloride
• CAS: 1308384-53-3
• 化学式: C₇H₅Cl₂FO₂S
• mdl: MFCD11976098
• 分子量: 243.086
• InChiKey: WRWQIURFCWLMRC-UHFFFAOYSA-N

物化性质

• 沸点：
  315.2±32.0 °C(Predicted)
• 密度：
  1.575±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-amino-1-propyl-3,4-dihydroquinolin-2-one 、 2-fluoro-4-chlorobenzylsulfonyl chloride 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以40%的产率得到1-(4-chloro-2-fluorophenyl)-N-(2-oxo-1-propyl-3,4-dihydroquinolin-6-yl)methanesulfonamide
  参考文献：
  名称：

  Small Molecule Compound for Enhancing Plant Stress Resistance

  摘要：

  本文公开了一种用于增强植物抗逆性的小分子化合物，其制备方法以及应用。具体公开了如公式I所示的化合物，其盐，光学异构体，外消旋体，溶剂合物或前体。此外，本发明的化合物是ABA的替代物，可以显著提高植物的抗逆性，因此具有极其广泛的应用前景。

  公开号：

  US20180360039A1

文献信息

• SMALL MOLECULE COMPOUND FOR ENHANCING PLANT STRESS RESISTANCE
  申请人：Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

  公开号：EP3342766A1

  公开（公告）日：2018-07-04

  Disclosed are a small molecule compound for enhancing plant stress resistance, a preparation method therefor, and application thereof. Specifically, disclosed are compounds as shown in formula I, salts thereof, optical isomers thereof, racemes thereof, solvates thereof, or precursors thereof. Moreover, the compound of the present invention is a substitute of ABA, can significantly improve the plant stress resistance, and thus has an extremely wide application prospect.

  公开了一种用于增强植物抗逆性的小分子化合物、其制备方法及其应用。具体而言，本发明公开了如式 I 所示的化合物、其盐类、其光学异构体、其外消旋体、其溶剂或其前体。此外，本发明的化合物是 ABA 的替代品，能显著提高植物的抗逆性，因此具有极其广泛的应用前景。
• Small molecule compound for enhancing plant stress resistance
  申请人：SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES

  公开号：US10842151B2

  公开（公告）日：2020-11-24

  Disclosed are a small molecule compound for enhancing plant stress resistance, a preparation method therefor, and application thereof. Specifically, disclosed are compounds as shown in formula I, salts thereof, optical isomers thereof, racemes thereof, solvates thereof, or precursors thereof. Moreover, the compound of the present invention is a substitute of ABA, can significantly improve the plant stress resistance, and thus has an extremely wide application prospect.

  公开了一种用于增强植物抗逆性的小分子化合物、其制备方法及其应用。具体而言，本发明公开了如式 I 所示的化合物、其盐类、其光学异构体、其外消旋体、其溶剂或其前体。此外，本发明的化合物是 ABA 的替代品，能显著提高植物的抗逆性，因此具有极其广泛的应用前景。
• Sulfonamide carboxamide compounds
  申请人：Inflazome Limited

  公开号：US11518739B2

  公开（公告）日：2022-12-06

  The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R 1 is a saturated or unsaturated, optionally substituted C 1 -C 15 hydrocarbyl group, wherein the atom of R 1 which is attached to the sulfur atom of the sulfonylurea group is not a ring atom of a cyclic group; and R 2 is a cyclic group substituted at the α-position, wherein R 2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP 3 .

  本发明涉及式（I）化合物： 其中 Q 选自 O 或 S；R 1 是饱和或不饱和、任选取代的 C 1 -C 15 烃基，其中 R 1 与磺酰脲基的硫原子相连的 R 1 原子不是环状基团的环原子；以及 R 2 是在α位被取代的环状基团，其中 R 2 可任选被进一步取代。本发明进一步涉及这类化合物的盐、溶液剂和原药，涉及包含这类化合物的药物组合物，涉及这类化合物在治疗和预防医学紊乱和疾病中的用途，特别是通过抑制 NLRP 3 .
• NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS
  申请人：Inflazome Limited

  公开号：US20200216389A1

  公开（公告）日：2020-07-09

  The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R 1 is a saturated or unsaturated, optionally substituted C 1 -C 15 hydrocarbyl group, wherein the atom of R 1 which is attached to the sulfur atom of the sulfonylurea group is not a ring atom of a cyclic group; and R 2 is a cyclic group substituted at the α-position, wherein R may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP 3 .
• [EN] NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE SULFONAMIDE CARBOXAMIDE
  申请人：INFLAZOME LTD

  公开号：WO2019034697A1

  公开（公告）日：2019-02-21

  The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated, optionally substituted C1-C15 hydrocarbyl group, wherein the atom of R1 which is attached to the sulfur atom of the sulfonylurea group is not a ring atom of a cyclic group; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.