4-[3-(4-fluorophenylsulfonamino)benzoyl]-1-methylpiperidine | 288157-12-0

• 分子结构分类: 有机化合物
• 英文名称: 4-[3-(4-fluorophenylsulfonamino)benzoyl]-1-methylpiperidine
• 英文别名: 4-fluoro-N-[3-(1-methylpiperidine-4-carbonyl)phenyl]benzenesulfonamide
• CAS: 288157-12-0
• 化学式: C₁₉H₂₁FN₂O₃S
• 分子量: 376.452
• InChiKey: DDFDDNZURGBSNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compositions and therapeutic methods utilizing a combination of a 5-HT1F inhibitor and an NSAID
  申请人：Plachetka R. John

  公开号：US20060178349A1

  公开（公告）日：2006-08-10

  The present invention is directed to compositions containing a 5-HT 1F -specific agonist that acts by blocking protein extravasation together with an NSAID. These compositions may be used to treat migraine and headache pain. The invention also includes methods in which these drugs are separately administered to a patient.

  本发明涉及含有 5-HT 1F -特异性激动剂与一种非甾体抗炎药一起发挥作用。这些组合物可用于治疗偏头痛和头痛。本发明还包括对患者分别施用这些药物的方法。
• 5-HT1F AGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1153013B1

  公开（公告）日：2007-10-31
• COMPOSITIONS AND THERAPEUTIC METHODS UTILIZING A COMBINATION OF A 5-HT1F INHIBITOR AND AN NSAID
  申请人：Pozen, Inc.

  公开号：EP1841427A2

  公开（公告）日：2007-10-10
• US6777428B1
  申请人：——

  公开号：US6777428B1

  公开（公告）日：2004-08-17
• [EN] 5-HT1F AGONISTS<br/>[FR] AGONISTES 5-HT1F
  申请人：LILLY CO ELI

  公开号：WO2000047559A2

  公开（公告）日：2000-08-17

  The present invention relates to a compound of formula (I) and a process for making; or a pharmaceutical acid addition salt thereof; which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal.