5-fluoro-1-propionyl-1H-pyrimidine-2,4-dione | 56058-99-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-fluoro-1-propionyl-1H-pyrimidine-2,4-dione
• 英文别名: 5-Fluoro-1-propionylpyrimidine-2,4(1H,3H)-dione；5-fluoro-1-propanoylpyrimidine-2,4-dione
• CAS: 56058-99-2
• 化学式: C₇H₇FN₂O₃
• 分子量: 186.143
• InChiKey: IQBDVJWBUMTCEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-Acetyl-5-fluoro-3-propanoylpyrimidine-2,4-dione 、 乙醇 以60%的产率得到
  参考文献：
  名称：

  KAMETANI TETSUJI; KIGASAWA KAZUO; HIIRAGI MINEHARU; WAKISAKA KIKUO; HAGA +, J. MED. CHEM., 1980, 23, NO 12, 1324-1329

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR DELIVERY OF HIGH-AFFINITY OXYGEN BINDING AGENTS TO TUMORS
  申请人：Vindico Nanobio Technology, Inc.

  公开号：EP2661275A2

  公开（公告）日：2013-11-13
• COMPOSITIONS AND METHODS FOR INDUCING NANOPARTICLE-MEDIATED MICROVASCULAR EMBOLIZATION OF TUMORS
  申请人：Vindico Nanobiotechnology, LLC.

  公开号：EP3177713A1

  公开（公告）日：2017-06-14
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF HIGH-AFFINITY OXYGEN BINDING AGENTS TO TUMORS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR DÉLIVRER AUX TUMEURS DES AGENTS SE LIANT À L'OXYGÈNE AVEC UNE AFFINITÉ ÉLEVÉE
  申请人：VINDICO NANOBIO TECHNOLOGY INC

  公开号：WO2012094679A2

  公开（公告）日：2012-07-12

  While tumor hypoxia is recognized as a key barrier to effective chemo and radiation therapy of solid tumor malignancies, and an important biological mediator of more aggressive tumor phenotype and behavior for over 50 years, prior attempts to improve tumor oxygenation have relied on increasing the total amount of oxygen bound to each molecule of natural hemoglobin (e.g. through hyperbaric oxygen treatments), increasing the ease of release of oxygen from hemoglobin (through the introduction of exogenous allosteric small molecules), or increasing the total amount of oxygen in the body by injecting perfluorocarbon emulsions, or polymerized or pegylated compositions of natural human or bovine hemoglobin. The embodiments provide a novel approach of introducing into the vascular system agents that possess inherently higher-affinities for molecular oxygen that that of natural human hemoglobin, and coupling these agents with inert carriers that shield them from unwanted biological interactions within the body.
• [EN] COMPOSITIONS AND METHODS FOR INDUCING NANOPARTICLE-MEDIATED MICROVASCULAR EMBOLIZATION OF TUMORS<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'INDUCTION D'UNE EMBOLISATION MICROVASCULAIRE DES TUMEURS À MÉDIATION PAR DES NANOPARTICULES
  申请人：VINDICO NANOBIO TECHNOLOGY INC

  公开号：WO2016022805A1

  公开（公告）日：2016-02-11

  Nanoparticle mediated microvascular embolization (NME) of tumor tissue may occur after systemic administration of PEM, leading to widespread shutdown of vascular flow, hemorrhage, and necrosis. PEM constructs are developed that incorporate large amounts of iron-containing protein, possess high oxygen affinities, and demonstrate delayed nitric oxide binding. Such properties induce selective NME of tumors after extravasation, and will likely enhance the effect of VEGFR TKIs and/or mTOR inhibitors.