2-((4-iodophenyl)amino)phenazine 5,10-dioxide | 1222360-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-((4-iodophenyl)amino)phenazine 5,10-dioxide
• CAS: 1222360-12-4
• 化学式: C₁₈H₁₂IN₃O₂
• 分子量: 429.217
• InChiKey: JRASDLNMBYZUFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.91
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-((4-iodophenyl)amino)phenazine 5,10-dioxide 在 sodium dithionite 作用下， 以30%的产率得到
  参考文献：
  名称：

  Iodine scanning of a phenazine inhibitor of vacuolar sorting

  摘要：

  Affinity reagents are often used to address the target identification problem in chemical genetics. The design of such reagents so that the linker does not occlude interactions with protein targets is an ongoing challenge. This work describes a systematic approach to synthesize derivatives of a bioactive that should avoid interference with binding to targets and be readily converted to affinity reagents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.106
• 作为产物：
  描述：

  苯并呋咱 、 4-hydroxy-4'-iododiphenylamine 在 sodium hydroxide 作用下， 以20%的产率得到2-((4-iodophenyl)amino)phenazine 5,10-dioxide
  参考文献：
  名称：

  Iodine scanning of a phenazine inhibitor of vacuolar sorting

  摘要：

  Affinity reagents are often used to address the target identification problem in chemical genetics. The design of such reagents so that the linker does not occlude interactions with protein targets is an ongoing challenge. This work describes a systematic approach to synthesize derivatives of a bioactive that should avoid interference with binding to targets and be readily converted to affinity reagents. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.106