N-(5-carboxypentyl)-4-(4-(dimethylamino)styryl)pyridinium bromide | 861692-00-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-carboxypentyl)-4-(4-(dimethylamino)styryl)pyridinium bromide
• 英文别名: 6-[4-[2-[4-(dimethylamino)phenyl]ethenyl]pyridin-1-ium-1-yl]hexanoic acid;bromide
• CAS: 861692-00-4
• 化学式: Br*C₂₁H₂₇N₂O₂
• 分子量: 419.362
• InChiKey: PIOUZVIFDZLPQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.86
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对二甲氨基苯甲醛 、 1-(5-Carboxy-pentyl)-2-methyl-pyridinium; bromide 、 哌啶 在 甲醇 、 乙醚 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以to give the product (6.7 g)的产率得到N-(5-carboxypentyl)-4-(4-(dimethylamino)styryl)pyridinium bromide
  参考文献：
  名称：

  Dimeric and trimeric nucleic acid dyes, and associated systems and methods

  摘要：

  本文提供二聚体和三聚体核酸染料，以及相关系统和方法。此类染料可以形成类似发夹的结构，使其能够通过按需释放机制染色核酸。例如，此类染料在缺少核酸时具有低背景荧光，在与核酸结合后具有高荧光。此处提供的染料可用于多种应用，例如实时PCR中的DNA定量。

  公开号：

  US07776567B2

文献信息

• Methods of using dyes in association with nucleic acid staining or detection and associated technology
  申请人：Mao Fei

  公开号：US20060211029A1

  公开（公告）日：2006-09-21

  Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

  提供使用染料和相关技术的方法。染料，例如单体染料或二聚体染料，可用于核酸凝胶染色应用和/或核酸检测应用。在这样的应用中，可以使用这样的染料和包含与强酸相关联的阴离子和与强碱相关联的阳离子的盐。二聚体染料，例如能够形成类似发夹结构的二聚体染料，可通过按需释放机制用于染色和/或检测核酸。在没有核酸的情况下具有低背景荧光，与核酸结合后具有高荧光的二聚体染料，可用于染色和/或检测核酸。
• METHODS OF USING DYES IN ASSOCIATION WITH NUCLEIC ACID STAINING OR DETECTION AND ASSOCIATED TECHNOLOGY
  申请人：Mao Fei

  公开号：US20100009454A1

  公开（公告）日：2010-01-14

  Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

  提供了使用染料及相关技术的方法。染料，如单体染料或二聚体染料，可用于核酸凝胶染色应用和/或核酸检测应用。这种染料和包含与强酸相关联的阴离子和与强碱相关联的阳离子的盐可以用于这种应用。一种二聚体染料，如能够形成类似发夹结构的二聚体染料，可通过按需释放机制用于染色和/或检测核酸。一种二聚体染料，在没有核酸存在时具有低背景荧光，与核酸结合后在核酸存在时具有高荧光，可用于染色和/或检测核酸。
• Methods of Using Dyes in Association with Nucleic Acid Staining or Detection and Associated Technology
  申请人：Biotium, Inc.

  公开号：US20140073058A1

  公开（公告）日：2014-03-13

  Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

  提供了使用染料及相关技术的方法。染料，如单体染料或二聚体染料，可用于核酸凝胶染色应用和/或核酸检测应用。这样的染料和包含与强酸相关联的阴离子和与强碱相关联的阳离子的盐可以在这种应用中使用。二聚体染料，如能够形成类似发夹状结构的二聚体染料，可以通过按需释放机制用于染色和/或检测核酸。在没有核酸存在时具有低背景荧光而在与核酸结合后具有高荧光的二聚体染料，可用于染色和/或检测核酸。
• Dyes and Labeled Molecules
  申请人：AlleLogic Biosciences Corporation

  公开号：US20140106349A1

  公开（公告）日：2014-04-17

  Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

  提供了二聚和三聚核酸染料，以及相关系统和方法。这样的染料可以形成类似发夹的结构，使其通过按需释放机制染色核酸。例如，这样的染料在没有核酸存在时具有低背景荧光，在与核酸结合后具有高荧光，例如。本文提供的染料可以在各种应用中有用，例如在实时PCR中用于DNA定量。
• Dyes and labeled molecules
  申请人：Mao Fei

  公开号：US08530195B2

  公开（公告）日：2013-09-10

  Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

  本文提供了二聚和三聚核酸染料及相关系统和方法。这样的染料可以形成类似发夹的结构，从而通过按需释放机制染色核酸。例如，这样的染料在缺乏核酸时具有低背景荧光，在与核酸结合后则具有高荧光。本文提供的染料可用于多种应用，例如实时PCR中的DNA定量等。