2-[(2,6-Dimethylphenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide | 1316215-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[(2,6-Dimethylphenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
• 英文别名: 2-(N-(2,6-dimethylphenyl)anilino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide
• CAS: 1316215-13-0
• 化学式: C₂₆H₃₁N₅O₃
• 分子量: 461.6
• InChiKey: JRKWOWIYKUDTNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Acetylon Pharmaceuticals, Inc.

  公开号：EP2526093B1

  公开（公告）日：2016-08-17
• BIOMARKERS TO IDENTIFY PATIENTS THAT WILL RESPOND TO TREATMENT AND TREATING SUCH PATIENTS
  申请人：Acetylon Pharmaceuticals, Inc.

  公开号：EP2839037B1

  公开（公告）日：2018-12-26
• Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof
  申请人：van Duzer John H.

  公开号：US20120083504A1

  公开（公告）日：2012-04-05

  The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
• Histone Deacetylase 6 Selective Inhibitors for the Treatment of Bone Disease
  申请人：Raje Noopur

  公开号：US20140378385A1

  公开（公告）日：2014-12-25

  This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule inhibitors such as reverse amide compounds.
• US8148526B1
  申请人：——

  公开号：US8148526B1

  公开（公告）日：2012-04-03