1-[[4-[4-(Imidazol-1-ylmethyl)phenyl]sulfonylphenyl]methyl]imidazole | 1312845-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[[4-[4-(Imidazol-1-ylmethyl)phenyl]sulfonylphenyl]methyl]imidazole
• CAS: 1312845-02-5
• 化学式: C₂₀H₁₈N₄O₂S
• 分子量: 378.455
• InChiKey: MOWBDIUJMCXNGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  78.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[[4-[4-(Imidazol-1-ylmethyl)phenyl]sulfonylphenyl]methyl]imidazole 、 1,4-二(溴甲基)-2,5-二甲氧基苯 以 乙腈 为溶剂， 反应 96.0h， 以65%的产率得到
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some novel dicationic sulphonophanes

  摘要：

  The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic fungus Candida albicans. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.063
• 作为产物：
  描述：

  咪唑 、 1-(4-(溴甲基)苯基磺酰基)-4-(溴甲基)苯 在 sodium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 48.17h， 以71%的产率得到1-[[4-[4-(Imidazol-1-ylmethyl)phenyl]sulfonylphenyl]methyl]imidazole
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some novel dicationic sulphonophanes

  摘要：

  The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic fungus Candida albicans. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.063

文献信息

• Synthesis and antimicrobial activity of some novel dicationic sulphonophanes
  作者：Perumal Rajakumar、Chinnadurai Satheeshkumar、Gunasekaran Mohanraj、Narayanasamy Mathivanan

  DOI：10.1016/j.ejmech.2011.03.063

  日期：2011.7

  The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic fungus Candida albicans. (C) 2011 Elsevier Masson SAS. All rights reserved.