acetoxymethyl 2-ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate | 147403-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: acetoxymethyl 2-ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
• 英文别名: acetyloxymethyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• CAS: 147403-16-5
• 化学式: C₂₈H₂₄N₄O₇
• 分子量: 528.521
• InChiKey: KQSOPQKCEWAFPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Benzimidazole derivative and use thereof
  申请人：Kuroita Takanobu

  公开号：US20050187269A1

  公开（公告）日：2005-08-25

  The present invention relates to a compound represented by the formula (I) wherein R 1 is a group represented by the formula wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently a hydrogen atom or a C 1-6 alkyl, or a salt thereof. The compound of the present invention is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and metabolic diseases such as diabetes and the like.

  本发明涉及一种化合物，其表示为式(I)，其中R1是由下式表示的基团，其中R2、R3、R4、R5、R6、R7和R8分别独立地是氢原子或C1-6烷基，或其盐。本发明的化合物可用作预防或治疗循环疾病（如高血压等）和代谢疾病（如糖尿病等）的药剂。
• Benzinidazole Derivative and Use As AII Receptor Antagonist
  申请人：Kuroita Takanobu

  公开号：US20060281795A1

  公开（公告）日：2006-12-14

  The present invention relates to a compound represented by the formula (I) wherein R 1 is a group represented by the formula wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently a hydrogen atom or a C 1-6 alkyl, or a salt thereof. The compound of the present invention is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and metabolic diseases such as diabetes and the like.

  本发明涉及一种由式(I)表示的化合物，其中R1是由式表示的基团其中R2、R3、R4、R5、R6、R7和R8各自独立地为氢原子或C1-6烷基或其盐。本发明的化合物可用作预防或治疗循环系统疾病，如高血压等，以及代谢性疾病，如糖尿病等的药物。
• Benzimidazole derivative and use as a II receptor antagonist
  申请人：Kuroita Takanobu

  公开号：US20090270464A1

  公开（公告）日：2009-10-29

  The present invention relates to a compound represented by the formula (I) wherein R 1 is a group represented by the formula wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each independently a hydrogen atom or a C 1-6 alkyl, or a salt thereof. The compound of the present invention is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and metabolic diseases such as diabetes and the like.

  本发明涉及一种化合物，其表示为公式（I），其中R1是由以下公式表示的基团： 其中R2、R3、R4、R5、R6、R7和R8各自独立地为氢原子或C1-6烷基，或其盐。本发明的化合物可用作预防或治疗循环系统疾病，如高血压等，以及代谢性疾病，如糖尿病等的药剂。
• Use of an angiotensin II antagonist as an ocular hypotensive agent
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0631780A1

  公开（公告）日：1995-01-04

  This invention relates to an ocular hypotensive agent which comprises a compound represented by the formula: wherein R¹ represents hydrogen or an optionally substituted hydrocarbon residue that may be bound via a hetero atom; R² represents hydrogen or a hydrocarbon residue that may have a substituent; R³ represents a group capable of forming an anion or a group capable of changing thereto; X is a covalent bond between the 2 benzene rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n represents 1 or 2; ring A is a benzene ring having 1 or 2 optional substituents in addition to the group represented by COOR², or a pharmaceutically acceptable salt thereof.

  本发明涉及一种降眼压剂，它由一种由式表示的化合物组成： 其中R¹代表氢或可通过杂原子结合的任选取代的烃残基；R²代表氢或可具有取代基的烃残基；R³代表能够形成阴离子的基团或能够转变为阴离子的基团；X是2个苯环之间的共价键或链长为1至2个原子的间隔物，作为相邻亚苯基和苯基之间的线性分子；n代表1或2；环A是除COOR²代表的基团外具有1或2个任选取代基的苯环，或其药学上可接受的盐。
• Benzimidazole derivative and its use as aii receptor antagonist
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2119715A1

  公开（公告）日：2009-11-18

  The invention relates to a process for preparing a compound of formula (I): wherein R1 is a group represented by the formula: wherein R2, R3, R4, R5, R6, R7 and R8 are each independently a hydrogen atom or a C1-6 alkyl, or a salt thereof, which comprises reacting a compound of formula (II): or a salt thereof, with an acylating agent; with thionyl chloride or oxalyl chloride and then with an alcohol; with an alkylating agent; or with an alcohol.

  本发明涉及一种制备式 (I) 化合物的工艺： 其中 R1 是由式表示的基团： 其中 R2、R3、R4、R5、R6、R7 和 R8 各自独立地为氢原子或 C1-6 烷基、 或其盐，其中包括反应式 (II) 的化合物： 或其盐与酰化剂反应；与亚硫酰氯或草酰氯反应，然后与醇反应；与烷化剂反应；或与醇反应。