3,3-ethylenedioxy-18(S),20(R)-dihydroxy-18-vinylpregn-5-ene | 164120-34-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3,3-ethylenedioxy-18(S),20(R)-dihydroxy-18-vinylpregn-5-ene
• CAS: 164120-34-7
• 化学式: C₂₅H₃₈O₄
• 分子量: 402.574
• InChiKey: MWGJUIFOJDBEPY-KTKBBFCESA-N

反应信息

• 作为反应物：
  描述：

  3,3-ethylenedioxy-18(S),20(R)-dihydroxy-18-vinylpregn-5-ene 在 水 、 溶剂黄146 作用下， 以 异丙醇 为溶剂， 反应 4.0h， 以33%的产率得到(18S,20R)-dihydroxy-18-vinylpregn-4-ene-3-one
  参考文献：
  名称：

  Synthesis of potential cytochrome P45011β-generated intermediates

  摘要：

  Cytochrome P-450(11 beta) is a key enzyme in the biosynthesis of aldosterone which catalyzes the transformation of 11--deoxycorticosterone (DOC) to aldosterone via three successive hydroxylations (at C-11 and at C-18). This enzyme is irreversibly inactivated by 18-VP 1 and 18-EP 4. In order to determine the mechanism of the inactivation, we have synthesized three potential reactive enzyme-generated intermediates 2, 3 and 5.

  DOI：

  10.1016/0040-4020(95)00099-t
• 作为产物：
  描述：

  乙烯基溴化镁 、 以 四氢呋喃 、 甲苯 为溶剂， 反应 16.0h， 以38.5%的产率得到3,3-ethylenedioxy-20-hydroxy-18-oxo-(but-4-enyl)-pregn-5-ene
  参考文献：
  名称：

  Synthesis of potential cytochrome P45011β-generated intermediates

  摘要：

  Cytochrome P-450(11 beta) is a key enzyme in the biosynthesis of aldosterone which catalyzes the transformation of 11--deoxycorticosterone (DOC) to aldosterone via three successive hydroxylations (at C-11 and at C-18). This enzyme is irreversibly inactivated by 18-VP 1 and 18-EP 4. In order to determine the mechanism of the inactivation, we have synthesized three potential reactive enzyme-generated intermediates 2, 3 and 5.

  DOI：

  10.1016/0040-4020(95)00099-t