1-Chloro-3-[4-[4-(3-chloro-2-hydroxypropoxy)phenyl]sulfanylphenoxy]propan-2-ol | 1314090-45-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1-Chloro-3-[4-[4-(3-chloro-2-hydroxypropoxy)phenyl]sulfanylphenoxy]propan-2-ol
• CAS: 1314090-45-3
• 化学式: C₁₈H₂₀Cl₂O₄S
• 分子量: 403.326
• InChiKey: GVANGGPOOVWKKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4,4'-二羟基二苯硫醚 在 cerium(III) chloride heptahydrate 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 35.17h， 生成 1-Chloro-3-[4-[4-(3-chloro-2-hydroxypropoxy)phenyl]sulfanylphenoxy]propan-2-ol
  参考文献：
  名称：

  [EN] BISPHENOL DERIVATIVE THERAPEUTICS AND METHODS FOR THEIR USE
  [FR] AGENTS THÉRAPEUTIQUES À BASE DE DÉRIVÉS DU BISPHÉNOL ET MÉTHODES POUR LEUR UTILISATION

  摘要：

  本发明提供具有公式（I）结构的化合物。这些化合物的用途包括治疗多种适应症，包括前列腺癌，同时还提供了涉及这些化合物的治疗方法。

  公开号：

  WO2011082488A1

文献信息

• Aromatic polythiol compound for optical material
  申请人：SKC CO., LTD.

  公开号：US11279673B2

  公开（公告）日：2022-03-22

  An embodiment relates to an aromatic polythiol compound for optical materials, and the aromatic polythiol compound according to the embodiment contains a phenyl group and a large number of sulfur atoms in its polythiol structure so that a polymerizable composition and an optical material obtained therefrom have excellent optical properties such as high refractive index and low specific gravity, as well as excellent mechanical properties such as low cure shrinkage; thus, they can be advantageously used for producing various plastic optical lenses such as eyeglass lenses and camera lenses.

  一个实施例涉及一种用于光学材料的芳香族聚硫醇化合物，根据该实施例的芳香族聚硫醇化合物在其聚硫醇结构中含有一个苯基和大量的硫原子，从而使可聚合组合物和由此获得的光学材料具有优异的光学性能，如高折射率和低比重，以及优异的机械性能，如低固化收缩率；因此，它们可有利地用于生产各种塑料光学镜片，如眼镜片和相机镜片。
• BISPHENOL DERIVATIVE THERAPEUTICS AND METHODS FOR THEIR USE
  申请人：Sadar Marianne D.

  公开号：US20130109758A1

  公开（公告）日：2013-05-02

  This invention provides compounds having a structure of Formula (I). Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
• AROMATIC POLYTHIOL COMPOUND FOR OPTICAL MATERIAL
  申请人：SKC CO., LTD.

  公开号：US20190292144A1

  公开（公告）日：2019-09-26

  An embodiment relates to an aromatic polythiol compound for optical materials, and the aromatic polythiol compound according to the embodiment contains a phenyl group and a large number of sulfur atoms in its polythiol structure so that a polymerizable composition and an optical material obtained therefrom have excellent optical properties such as high refractive index and low specific gravity, as well as excellent mechanical properties such as low cure shrinkage; thus, they can be advantageously used for producing various plastic optical lenses such as eyeglass lenses and camera lenses.