N-{(1S,4R)-cis-4-[3-(4-Fluorophenoxy)phenoxy]-2-cyclopenten-1-yl}-N-hydroxyurea | 179465-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{(1S,4R)-cis-4-[3-(4-Fluorophenoxy)phenoxy]-2-cyclopenten-1-yl}-N-hydroxyurea
• 英文别名: N-((1S,4R)-4-(3-(4-Fluorophenoxy)phenoxy)-2-cyclopenten-1-yl)-N-hydroxyurea；1-[(1S,4R)-4-[3-(4-fluorophenoxy)phenoxy]cyclopent-2-en-1-yl]-1-hydroxyurea
• CAS: 179465-71-5
• 化学式: C₁₈H₁₇FN₂O₄
• 分子量: 344.342
• InChiKey: CJFQUWMJNVTKDJ-DYVFJYSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  85
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Solid pharmaceutical dispersions with enhanced bioavailabilty
  申请人：Pfizer Products Inc.

  公开号：EP1741424A2

  公开（公告）日：2007-01-10

  Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.

  由难溶性药物和羟丙基甲基纤维素醋酸酯琥珀酸盐（HPMCAS）组成的喷雾干燥固体分散体可提高药物在使用环境中的水溶性和/或生物利用度。
• ARYLOXYCYCLOALKENYL AND ARYLOXYIMINOCYCLOALKENYLHYDROXYUREAS AS 5-LIPOXYGENASE INHIBITORS
  申请人：PFIZER INC.

  公开号：EP0790981B1

  公开（公告）日：1999-09-08
• SOLID PHARMACEUTICAL DISPERSIONS WITH ENHANCED BIOAVAILABILITY
  申请人：Curatolo William J.

  公开号：US20120288542A1

  公开（公告）日：2012-11-15

  Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
• PHARMACEUTICAL SOLID DISPERSIONS
  申请人：Babcock Walter C.

  公开号：US20130029965A1

  公开（公告）日：2013-01-31

  A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
• US8263128B2
  申请人：——

  公开号：US8263128B2

  公开（公告）日：2012-09-11