4-(biphenyl-4-ylamino)-thieno[2,3-c]pyridine-2-carbonitrile | 870243-76-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(biphenyl-4-ylamino)-thieno[2,3-c]pyridine-2-carbonitrile
• 英文别名: 4-(4-phenylanilino)thieno[2,3-c]pyridine-2-carbonitrile
• CAS: 870243-76-8
• 化学式: C₂₀H₁₃N₃S
• 分子量: 327.409
• InChiKey: ZAFPGAXUAAOKFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(biphenyl-4-ylamino)-thieno[2,3-c]pyridine-2-carbonitrile 在 sodium azide 、 氯化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 N-(4-phenylphenyl)-2-(1H-1,2,3,4-tetrazol-5-yl)thieno[2,3-c]pyridin-4-amine
  参考文献：
  名称：

  Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-α production

  摘要：

  COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1 beta via the ERK/MAP kinase pathway. As TNF-alpha and IL-1 beta are clinically validated targets for therapeutic intervention in rheumatoid arthritis (RA), blocking COT provides a potential avenue for amelioration of disease. Herein we describe identification of a cellular active selective small molecule inhibitor of COT kinase. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.088
• 作为产物：
  描述：

  4-(biphenyl-4-ylamino)-thieno[2,3-c]pyridine-2-carboxylic acid amide 在 吡啶 、 三氟乙酸 作用下， 反应 6.0h， 生成 4-(biphenyl-4-ylamino)-thieno[2,3-c]pyridine-2-carbonitrile
  参考文献：
  名称：

  Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-α production

  摘要：

  COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1 beta via the ERK/MAP kinase pathway. As TNF-alpha and IL-1 beta are clinically validated targets for therapeutic intervention in rheumatoid arthritis (RA), blocking COT provides a potential avenue for amelioration of disease. Herein we describe identification of a cellular active selective small molecule inhibitor of COT kinase. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.088

文献信息

• Kinase inhibitors as therapeutic agents
  申请人：Cusack Kevin

  公开号：US20060074102A1

  公开（公告）日：2006-04-06

  A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

  式(I)化合物或其药学上可接受的盐，其中取代基如本文所定义，可用作激酶抑制剂。
• KINASE INHIBITORS AS THERAPEUTIC AGENTS
  申请人：ABBOTT LABORATORIES

  公开号：EP1753428A2

  公开（公告）日：2007-02-21
• [EN] KINASE INHIBITORS AS THERAPEUTIC AGENTS<br/>[FR] INHIBITEURS DE KINASES EN TANT QU'AGENTS THERAPEUTIQUES
  申请人：ABBOTT LAB

  公开号：WO2005110410A2

  公开（公告）日：2005-11-24

  A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.