1,3-dichloro-2-(1,2-dibromoethyl)benzene | 258345-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-dichloro-2-(1,2-dibromoethyl)benzene
• CAS: 258345-73-2
• 化学式: C₈H₆Br₂Cl₂
• 分子量: 332.85
• InChiKey: WXVFGTHZGXWNTC-UHFFFAOYSA-N

物化性质

• 沸点：
  309.2±37.0 °C(Predicted)
• 密度：
  1.921±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.82
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  1,3-dichloro-2-(1,2-dibromoethyl)benzene 在 sodium tetrahydroborate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.67h， 以63%的产率得到1,3-二氯-2-乙基苯
  参考文献：
  名称：

  Studies on 6-Aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones

  摘要：

  From our quantitative structure-activity relationship (QSAR) study on a large set of 6-aminoquinolones, which indicated that a group larger than methyl could be allocated at C-8 position, we have synthesized two new series of 6-aminoquinolones characterized by the presence of an ethyl or a methoxy group at C-8 position. The antibacterial evaluation shows that, while the 8-ethyl derivatives were devoid of any antibacterial activity, the introduction of methoxy group gave compounds with good antibacterial activity, especially against Gram-positive bacteria. A tentative explanation of the different behaviours among the 8-substituted analogues is given taking into account both the length and electronic properties of the C-8 groups. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00207-2
• 作为产物：
  描述：

  2,6-二氯苯乙烯 在 溴 作用下， 以 四氯化碳 为溶剂， 反应 2.0h， 生成 1,3-dichloro-2-(1,2-dibromoethyl)benzene
  参考文献：
  名称：

  Visible-Light-Induced Regioselective C(sp³)-H Acyloxylation of Aryl-2H-azirines with (Diacetoxy)iodobenzene

  摘要：

  A visible-light-promoted regioselective coupling of C(sp(3))-H of aryl-2H-azirine and (diacetoxy)-iodobenzene has been reported. Rose Bengal as an organo-photoredox catalyst has been used in this reaction. The reaction proceeds under aerobic condition at room temperature. A variety of aryl-2H-azirines gives the corresponding acyloxylated azirines under this reaction conditions. The reaction goes through a radical pathway. The protocol is also applicable on gram-scale synthesis.

  DOI：

  10.1021/acs.joc.9b01625