2-(6-(Cyclohexylamino)pyrimidin-4-ylamino)ethan-1-ol | 1313491-56-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(6-(Cyclohexylamino)pyrimidin-4-ylamino)ethan-1-ol
• 英文别名: 2-[[6-(cyclohexylamino)pyrimidin-4-yl]amino]ethanol
• CAS: 1313491-56-3
• 化学式: C₁₂H₂₀N₄O
• 分子量: 236.317
• InChiKey: DFTXDSDDZUKFFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  70.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  环己胺 在 N,N-二异丙基乙胺 作用下， 以 异丙醇 、 正丁醇 为溶剂， 反应 7.0h， 生成 2-(6-(Cyclohexylamino)pyrimidin-4-ylamino)ethan-1-ol
  参考文献：
  名称：

  [EN] SUBSTITUTED PYRIDINES AND PYRIMIDINES FOR THE PRODUCTION OF CARDIOMYOCYTE - LIKE CELLS
  [FR] PYRIDINES ET PYRIMIDINES SUBSTITUÉES

  摘要：

  公开号：

  WO2011079343A3

文献信息

• SUBSTITUTED PYRIDINES AND PYRIMIDINES
  申请人：Mihovilovic Marko

  公开号：US20120294835A1

  公开（公告）日：2012-11-22

  Provided is a compound of formula (I), and/or salt thereof, wherein the radicals have various meanings, a process for producing cardiomyocyte-like cells from mammalian cells by culturing mammalian cells in the presence of the compound of formula (I), the pharmaceutical use of compounds of formula (I) for producing cardiomyocyte-like cells from omnipotent, pluripotent, or lineage committed mammalian cells, and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.

  提供的是式（I）的化合物和/或其盐， 其中基团具有各种含义，一种从哺乳动物细胞中培养类心肌细胞的方法，通过在存在式（I）的化合物的情况下培养哺乳动物细胞，化合物式（I）用于从全能、多能或已分化的哺乳动物细胞中产生类心肌细胞的药用途，以及用于治疗与心脏功能受损有关的疾病的由此产生的类心肌细胞。
• Substituted pyridines and pyrimidines
  申请人：Mihovilovic Marko

  公开号：US08986994B2

  公开（公告）日：2015-03-24

  Provided are compounds of formula (I) and/or salts thereof, of the class of substituted pyridines and pyrimidines, useful for inducing cardiomyogenesis, a process for producing cardiomyocyte-like cells from mammalian cells by culturing mammalian cells in the presence of the compound of formula (I), the pharmaceutical use of compounds of formula (I) for producing cardiomyocyte-like cells from omnipotent, pluripotent, or lineage committed mammalian cells, and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.

  提供了式（I）的化合物和/或其盐，属于取代吡啶和嘧啶类，可用于诱导心肌发生作用。通过在化合物（I）的存在下培养哺乳动物细胞，从而从哺乳动物细胞中产生类心肌细胞的过程，化合物（I）的制药用途用于从全能、多能或分化系承诺的哺乳动物细胞中产生类心肌细胞，以及用于治疗与心脏功能受损有关的疾病所产生的类心肌细胞。
• SUBSTITUTED PYRIDINES AND PYRIMIDINES FOR THE PRODUCTION OF CARDIOMYOCYTE-LIKE CELLS
  申请人：Technische Universität Wien

  公开号：EP2519501A2

  公开（公告）日：2012-11-07
• US8986994B2
  申请人：——

  公开号：US8986994B2

  公开（公告）日：2015-03-24
• [EN] SUBSTITUTED PYRIDINES AND PYRIMIDINES<br/>[FR] PYRIDINES ET PYRIMIDINES SUBSTITUÉES
  申请人：UNIV WIEN TECH

  公开号：WO2011079343A2

  公开（公告）日：2011-07-07

  A process for the production of cardiomocyte-like cells from mammalian cells, comprising cultering mammalian cells in the presence of a compound of formula (I) wherein the radicals have various meanings, compounds of formula (I), wherein the radicals have various meanings and the pharmaceutical use of compounds of formula (I) for the production of cardiomyocyte-like cells from omnipotent, pluripotent or lineage committed mammalian cells and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.