4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-[[(2R)-oxolan-2-yl]methyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide | 623152-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-[[(2R)-oxolan-2-yl]methyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
• CAS: 623152-69-2
• 化学式: C₂₄H₂₈N₆O₃
• 分子量: 448.525
• InChiKey: ACIFWYVJXINMRS-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Pyrrolo-Triazine Aniline Compounds Useful As Kinase Inhibitors
  申请人：Dyckman Alaric

  公开号：US20090105243A1

  公开（公告）日：2009-04-23

  Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Z are as described in the specification.
• PYRROLO-TRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：Dyckman Alaric

  公开号：US20100240646A1

  公开（公告）日：2010-09-23

  Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Z are as described in the specification.